Results 11 to 20 of about 306,822 (268)
Modifying the Mitochondrial Genome [PDF]
Cell Metabolism, 2016 Human mitochondria produce ATP and metabolites to support development and maintain cellular homeostasis. Mitochondria harbor multiple copies of a maternally inherited, non-nuclear genome (mtDNA) that encodes for 13 subunit proteins of the respiratory chain.
Patananan, Alexander N +3 more
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The ageing mitochondrial genome [PDF]
Nucleic Acids Research, 2007 The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process.
Krishnan, Kim J. +3 more
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Lophotrochozoan mitochondrial genomes [PDF]
Integrative and Comparative Biology, 2006 Progress in both molecular techniques and phylogenetic methods has challenged many of the interpretations of traditional taxonomy. One example is in the recognition of the animal superphylum Lophotrochozoa (annelids, mollusks, echiurans, platyhelminthes, brachiopods, and other phyla), although the relationships within this group and the inclusion of ...
Valles, Yvonne, Boore, Jeffrey L.
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Editing the Mitochondrial Genome
New England Journal of Medicine, 2020 Mending Mitochondrial Mutation For most patients with mitochondrial disorders, most of which are caused by mutations in genes in the mitochondrial genome, only symptomatic treatment is available.
Maria Falkenberg, Michio Hirano
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Mitochondrial helicases and mitochondrial genome maintenance [PDF]
Mechanisms of Ageing and Development, 2010 Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of ...
de Souza-Pinto, Nadja C +4 more
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Nature Communications, 2019 The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has ...
Simonetta Andreazza +15 more
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Nature Communications, 2016 The post-transcriptional 5-methylcytosine (m5C) modification occurs in a wide range of nuclear-encoded RNAs. Here the authors identify the mitochondrial tRNA-Met as a target for the m5C methyltransferase NSun3—found mutated in a mitochondrial disease ...
Lindsey Van Haute +18 more
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Mitochondrial DNA. Part B. Resources, 2022 Crematogaster matsumurai (Forel 1901) is an important arboreal ant species commonly found on Phyllostachys heterocycla (Carr.) in Lishui, Zhejiang, China. This study analyzed the mitochondrial genome sequence of C.
Jin-chao Wang +6 more
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Transformation of the mitochondrial genome
The International Journal of Developmental Biology, 2013 Although mitochondrial transformation is highly desirable in mammals and plants, it is only possible in two unicellular organisms, the budding yeast Saccharomyces cerevisiae and the unicellular green alga Chlamydomonas reinhardtii. Here, we give an overview of the attempts made to transform mitochondria of mammals and plants and the possible reasons ...
Larosa, Véronique, Remacle, Claire
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The Insights into Mitochondrial Genomes of Sunflowers [PDF]
Plants, 2021 The significant difference in the mtDNA size and structure with simultaneous slow evolving genes makes the mitochondrial genome paradoxical among all three DNA carriers in the plant cell. Such features make mitochondrial genome investigations of particular interest.
Maksim S. Makarenko +3 more
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