Results 41 to 50 of about 1,628,733 (342)

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

Cell Reports
Summary: Mitochondrial calcium (Ca2+) uptake augments metabolic processes and buffers cytosolic Ca2+ levels; however, excessive mitochondrial Ca2+ can cause cell death.
Madeleine J. Twyning, Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej, Susanna Campesan, Ana Terriente-Felix, Lewis Collins, Federica De Lazzari, Flaviano Giorgini, Alexander J. Whitworth   +9 more
doaj   +1 more source

Origin of minicircular mitochondrial genomes in red algae

Nature Communications, 2023
Eukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur.
Yongsung Lee, Chung Hyun Cho, Chanyoung Noh, Ji Hyun Yang, Seung In Park, Yu Min Lee, John A. West, Debashish Bhattacharya, Kyubong Jo, Hwan Su Yoon   +9 more
doaj   +1 more source

High and Variable Rates of Repeat-Mediated Mitochondrial Genome Rearrangement in a Genus of Plants

Molecular biology and evolution, 2018
For 30 years, it has been clear that angiosperm mitochondrial genomes evolve rapidly in sequence arrangement (i.e., synteny), yet absolute rates of rearrangement have not been measured in any plant group, nor is it known how much these rates vary.
L. W. Cole, Wenhu Guo, Jeffrey P. Mower, J. Palmer   +3 more
semanticscholar   +1 more source

Failure is not an option – mitochondrial genome segregation in trypanosomes

Journal of Cell Science, 2018
Unlike most other model eukaryotes, Trypanosoma brucei and its relatives have a single mitochondrion with a single-unit mitochondrial genome that is termed kinetoplast DNA (kDNA). Replication of the kDNA is coordinated with the cell cycle.
A. Schneider, T. Ochsenreiter
semanticscholar   +1 more source

Screening for the ancient polar bear mitochondrial genome reveals low integration of mitochondrial pseudogenes (numts) in bears

Mitochondrial DNA. Part B. Resources, 2017
Phylogenetic analyses of nuclear and mitochondrial genomes indicate that polar bears captured the brown bear mitochondrial genome 160,000 years ago, leading to an extinction of the original polar bear mitochondrial genome.
Fritjof Lammers, Axel Janke, Cornelia Rücklé, Vera Zizka, Maria A. Nilsson   +4 more
doaj   +1 more source

Characterization and phylogenetic analysis of the complete mitochondrial genome of Aspergillus sp. (Eurotiales: Eurotiomycetidae)

Mitochondrial DNA. Part B. Resources, 2019
In the present study, we presented the complete mitochondrial genome of Aspergillus sp. The complete mitochondrial genome of Aspergillus sp. was composed of circular DNA molecules, with a total length of 31,374 bp.
Cheng Chen, Rongtao Fu, Jian Wang, Rongping Hu, Xingyue Li, Xi Luo, Xuejuan Chen, Daihua Lu   +7 more
doaj   +1 more source

Oxygen Glucose Deprivation Induced Prosurvival Autophagy Is Insufficient to Rescue Endothelial Function

Frontiers in Physiology, 2020
Endothelial dysfunction, referring to a disturbance in the vascular homeostasis, has been implicated in many disease conditions including ischemic/reperfusion injury and atherosclerosis.
Venkateswaran Natarajan, Tania Mah, Chen Peishi, Shu Yi Tan, Ritu Chawla, Thiruma Valavan Arumugam, Adaikalavan Ramasamy, Karthik Mallilankaraman, Karthik Mallilankaraman   +8 more
doaj   +1 more source

Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

Nucleic Acids Research, 2018
N 6-methyldeoxyadenosine (6mA) is a well-characterized DNA modification in prokaryotes but reports on its presence and function in mammals have been controversial.
C. W. Koh, Y. T. Goh, Joel D. W. Toh, S. P. Neo, Sarah B. Ng, J. Gunaratne, Yong-Gui Gao, S. Quake, W. Burkholder, W. S. Goh   +9 more
semanticscholar   +1 more source

The mitochondrial brain: From mitochondrial genome to neurodegeneration

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
Mitochondrial DNA mutations are an important cause of neurological disease. The clinical presentation is very varied in terms of age of onset and different neurological signs and symptoms. The clinical course varies considerably but in many patients there is a progressive decline, and in some evidence of marked neurodegeneration.
Turnbull, H, Lax, N, Diodato, D, Ansorge, O, Turnbull, D   +4 more
openaire   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source