Results 121 to 130 of about 704,132 (300)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Rab11b is necessary for mitochondrial integrity and function in gut epithelial cells

Frontiers in Cell and Developmental Biology
IntroductionThe RAB11 family of small GTPases are intracellular regulators of membrane and vesicular trafficking. We recently reported that RAB11A and RAB11B redundantly regulate spindle dynamics in dividing gut epithelial cells.
Ivor Joseph, Jiangmeng Han, Jared Bianchi-Smak, Jiaxing Yang, Jagannatham Naidu Bhupana, Jagannatham Naidu Bhupana, Juan Flores, Jack Delucia, Tracy S. Tran, James R. Goldenring, Edward M. Bonder, Nan Gao, Nan Gao   +12 more
doaj   +1 more source

Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis

Toxicology Reports, 2018
Arsenic, being a global pollutant needs a potential remedy which could fight against its associated toxicities. Ellagic acid (EA) is a known agent for its anti-inflammatory, antioxidant and antiapoptotic effects, and it is commonly found in fruits.
Fakiha Firdaus, Mohd Faraz Zafeer, Ehraz Anis, Masood Ahmad, Mohammad Afzal   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.

PLoS ONE, 2014
Mitochondria are involved in the regulation of cell differentiation processes, but its function changes and molecular mechanisms are not yet clear. In this study, we found that mitochondrial functions changed obviously when K562 cells were induced to ...
Rui Huang, Long Zhao, Hui Chen, Rong-Hua Yin, Chang-Yan Li, Yi-Qun Zhan, Jian-Hong Zhang, Chang-hui Ge, Miao Yu, Xiao-Ming Yang   +9 more
doaj   +1 more source

Simultaneous imaging of cell and mitochondrial membrane potentials

Biophysical Journal, 1989
The distribution of charged membrane-permeable molecular probes between intracellular organelles, the cytoplasm, and the outside medium is governed by the relative membrane electrical potentials of these regions through coupled equilibria described by the Nernst equation. A series of highly fluorescent cationic dyes of low membrane binding and toxicity
Farkas, D.L., Wei, M.D., Febbroriello, P., Carson, J.H., Loew, L.M.   +4 more
openaire   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Hypothesis on skeletal muscle aging : mitochondrial adenine nucleotide translocator decreases reactive oxygen species production while preserving coupling efficiency

Frontiers in Physiology, 2015
Mitochondrial membrane potential is the major regulator of mitochondrial functions, including coupling efficiency and production of reactive oxygen species (ROS). Both functions are crucial for cell bioenergetics.
Philippe eDIOLEZ, Isabelle eBourdel-Marchasson, Isabelle eBourdel-Marchasson, Guillaume eCalmettes, Philippe ePasdois, Dominique eDetaille, Richard eRouland, Gilles eGouspillou   +7 more
doaj   +1 more source

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source