Results 91 to 100 of about 4,850,535 (301)

Protein-induced modulation of chloroplast membrane morphology [PDF]

, 2012
Organelles are surrounded by membranes with a distinct lipid and protein composition. While it is well established that lipids affect protein functioning and vice versa, it has been only recently suggested that elevated membrane protein concentrations ...
Maik S Sommer, Enrico eSchleiff, Machettira, Anu Bheemaiah, Anu B. Machettira, Englich, Gisela, Anu B Machettira, Benjamin LM Weis, Lucia E. Groß, Giesela eEnglich, Enrico Schleiff, Weis, Benjamin L., Gisela Englich, Lucia E Groß, Schleiff, Enrico, Königer, Martina, Martina eKöniger, Bodo Tillmann, Groß, Lucia E., Sommer, Maik Sascha, Benjamin L. Weis, Bodo eTillmann, Martina Königer, Tillmann, Bodo, Maik S. Sommer   +23 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.

PLoS ONE, 2014
Mitochondria are involved in the regulation of cell differentiation processes, but its function changes and molecular mechanisms are not yet clear. In this study, we found that mitochondrial functions changed obviously when K562 cells were induced to ...
Rui Huang, Long Zhao, Hui Chen, Rong-Hua Yin, Chang-Yan Li, Yi-Qun Zhan, Jian-Hong Zhang, Chang-hui Ge, Miao Yu, Xiao-Ming Yang   +9 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

TIM23-mediated insertion of transmembrane alpha-helices into the mitochondrial inner membrane [PDF]

, 2011
While overall hydrophobicity is generally recognized as the main characteristic of transmembrane (TM) alpha-helices, the only membrane system for which there are detailed quantitative data on how different amino acids contribute to the overall efficiency
Koji Yamano, Björkholm, Patrik, Kim, Hyun, von Heijne, Gunnar, Toshiya Endo, Botelho, Salomé Calado, Reichert, Andreas S., Patrik Björkholm, Kim, Hyun,, Reichert, Andreas, Endo, Toshiya, Hyun Kim, Österberg, Marie,, Salomé Calado Botelho, Marie Österberg, von Heijne, Gunnar,, Österberg, Marie, Andreas S Reichert, Björkholm, Patrik,, Yamano, Koji, Heijne, Gunnar von, Botelho, Salomé Calado,, Gunnar von Heijne   +22 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The Role of Phospholipids in Mitochondrial Dynamics and Associated Diseases

Frontiers in Bioscience-Landmark
The bioenergetic machinery of the cell is protected and structured within two layers of mitochondrial membranes. The mitochondrial inner membrane is extremely rich in proteins, including respiratory chain complexes, substrate transport proteins, ion ...
Solenn Plouzennec, Juan Manuel Chao de la Barca, Arnaud Chevrollier   +2 more
doaj   +1 more source

Disruption of a putative mitochondrial oxaloacetate shuttle protein in Aspergillus carbonarius results in secretion of malic acid at the expense of citric acid production

BMC Biotechnology, 2019
Background In filamentous fungi, transport of organic acids across the mitochondrial membrane is facilitated by active transport via shuttle proteins.
Lei Yang, Tore Linde, Abeer H. Hossain, Mette Lübeck, Peter J. Punt, Peter S. Lübeck   +5 more
doaj   +1 more source

Solute channels of the outer membrane: from bacteria to chloroplasts [PDF]

, 2007
Chloroplasts, unique organelles of plants, originated from endosymbiosis of an ancestor of today's cyanobacteria with a mitochondria-containing host cell. It is assumed that the outer envelope membrane, which delimits the chloroplast from the surrounding
Philippar, Katrin, Soll, Jürgen, Duy, Daniela   +2 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source