Results 1 to 10 of about 10,675,471 (331)

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy [PDF]

Nature Communications, 2022
Mitophagy activation is mediated by mitochondrial depolarization. Here, the authors show that mitochondrial protein misfolding can activate mitophagy in a depolarization-independent manner mediated by a protein import reduction.
Jonas Benjamin Michaelis, Melinda Elaine Brunstein, Süleyman Bozkurt, Ludovico Alves, Martin Wegner, Manuel Kaulich, Christian Pohl, Christian Münch   +7 more
doaj   +3 more sources

Mitochondrial protein import clogging as a mechanism of disease [PDF]

eLife, 2023
Mitochondrial biogenesis requires the import of >1,000 mitochondrial preproteins from the cytosol. Most studies on mitochondrial protein import are focused on the core import machinery.
Liam P Coyne, Xiaowen Wang, Jiyao Song, Ebbing de Jong, Karin Schneider, Paul T Massa, Frank A Middleton, Thomas Becker, Xin Jie Chen   +8 more
doaj   +3 more sources

Structural basis of mitochondrial protein import by the TIM23 complex. [PDF]

Nature, 2023
Mitochondria import nearly all of their approximately 1,000–2,000 constituent proteins from the cytosol across their double-membrane envelope^ 1 – 5 .
Sim SI, Chen Y, Lynch DL, Gumbart JC, Park E.   +4 more
europepmc   +2 more sources

A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

Cell Metabolism, 2021
Summary The architecture of cristae provides a spatial mitochondrial organization that contains functional respiratory complexes. Several protein components including OPA1 and MICOS complex subunits organize cristae structure, but upstream regulatory ...
Steven P. Gygi, Elizabeth A Perry, Pere Puigserver   +2 more
exaly   +2 more sources

Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases [PDF]

Frontiers in Physiology, 2023
Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery and subsequently cleaved to yield the mature protein.
Ashley L. Reed, Wayne Mitchell, Andrei T. Alexandrescu, Nathan N. Alder   +3 more
doaj   +2 more sources

Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1 [PDF]

The Journal of Clinical Investigation
Most mitochondrial proteins are nucleus-encoded, translated in the cytosol, and imported into the mitochondria. Through gene expression analysis and functional assays, we demonstrated that mitochondrial protein import was increased in acute myeloid ...
Matthew Tcheng, Veronique Voisin, Geethu Emily Thomas, Anastasija A. Piric, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Ali Chegini, Nathan Duong, Ross S. Mancini, Stefan Quinn W. Currie, Zaynab Mamai, Brady Stock, Shahbaz Khan, Yulia Jitkova, Chaitra Sarathy, Edward Ayoub, Po Yee Mak, Andrea Arruda, Thomas Kislinger, Mark A. Reed, Bing Z. Carter, Michael Andreeff, Steven M. Kornblau, Mark D. Minden, Siavash Vahidi, Aaron D. Schimmer   +29 more
doaj   +2 more sources

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40 [PDF]

Advanced Science
SUMOylation, a reversible post‐translational modification, regulates various mitochondrial processes, including biogenesis, dynamics, mitophagy, and the mitochondrial unfolded protein response.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
doaj   +2 more sources

Functional Interaction Between Toc75 POTRA1 Domain and Tic22‐III in the Intermembrane Space During Chloroplast Protein Import [PDF]

Plant Direct
Chaperones are essential for facilitating the import of nuclear‐encoded precursor proteins into chloroplasts. In the intermembrane space (IMS) of the chloroplasts, this process is mediated by the transport‐associated domains (POTRA) of the translocon at ...
Rajneesh Singhal, Danny J. Schnell
doaj   +2 more sources

Metabolic regulation of misfolded protein import into mitochondria [PDF]

eLife
Mitochondria are the cellular energy hub and central target of metabolic regulation. Mitochondria also facilitate proteostasis through pathways such as the ‘mitochondria as guardian in cytosol’ (MAGIC) whereby cytosolic misfolded proteins (MPs) are ...
Yuhao Wang, Linhao Ruan, Jin Zhu, Xi Zhang, Alexander Chih-Chieh Chang, Alexis Tomaszewski, Rong Li   +6 more
doaj   +2 more sources

Principles of cotranslational mitochondrial protein import. [PDF]

Cell
Zhu Z, Mallik S, Stevens TA, Huang R, Levy ED, Shan SO.   +5 more
europepmc   +2 more sources