Results 21 to 30 of about 10,675,471 (331)

A mitochondrion-free eukaryote contains proteins capable of import into an exogenous mitochondrion-related organelle

Open Biology, 2023
The endobiotic flagellate Monocercomonoides exilis is the only known eukaryote to have lost mitochondria and all its associated proteins in its evolutionary past.
Yi-Kai Fang, Zuzana Vaitová, Vladimir Hampl   +2 more
doaj   +1 more source

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

Molecules and Cells, 2021
Summary Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochondrial protein import machinery cause human pathologies.
J. Schäfer, Süleyman Bozkurt, J. Michaelis, Kevin Klann, Christian Münch   +4 more
semanticscholar   +1 more source

Protein Import Into Mitochondria [PDF]

IUBMB Life, 2001
AbstractMost mitochondrial proteins are encoded by the nuclear genome and thus have to be imported into mitochondria from the cytosol. Protein translocation across and into the mitochondrial membranes is a multistep process facilitated by the coordinated action of at least four specialized translocation systems in the outer and inner membranes of ...
S A, Paschen, W, Neupert
openaire   +2 more sources

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin.
Stefan Geldon, Erika Fernández-Vizarra, Kostas Tokatlidis   +2 more
doaj   +1 more source

Mitochondrial protein import [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of
Hartl, Franz-Ulrich, Pfanner, Nikolaus, Nicholson, Donald W., Neupert, Walter   +3 more
openaire   +4 more sources

Protein import into plant mitochondria: signals, machinery, processing, and regulation.

Journal of Experimental Botany, 2014
James Whelan, Elzbieta Glaser, Pedro Filipe Teixeira   +2 more
exaly   +2 more sources

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert, Lill, Roland, Harkness, Troy A.A.,, van der Klei, Ida, Neupert, Walter, Harkness, Troy A. A., Klei, Ida J. van der, TA Harkness, Klei, Ida van der,, Nargang, Frank E.,, I van der Klei, Neupert, Walter,, Lill, Roland,, van der Klei, Ida ; id_orcid, Nargang, Frank E., FE Nargang, R Lill   +16 more
core   +3 more sources

Trypanosoma brucei Pex13.2 Is an Accessory Peroxin That Functions in the Import of Peroxisome Targeting Sequence Type 2 Proteins and Localizes to Subdomains of the Glycosome

mSphere, 2020
Kinetoplastid parasites, including Trypanosoma brucei, Trypanosoma cruzi, and Leishmania, harbor unique organelles known as glycosomes, which are evolutionarily related to peroxisomes.
Logan P. Crowe, Christina L. Wilkinson, Kathleen R. Nicholson, Meredith T. Morris   +3 more
doaj   +1 more source

Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer

FEBS Letters, 2020
The majority of proteins localised to mitochondria are encoded by the nuclear genome, with approximately 1500 proteins imported into mammalian mitochondria.
Catherine S. Palmer, Alexander J. Anderson, Diana Stojanovski   +2 more
semanticscholar   +1 more source

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Pfanner, Nikolaus, Tropschug, Maximilian, Neupert, Walter   +2 more
core   +1 more source