A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease [PDF]
Cells, 2021 The central role mitochondria play in cellular homeostasis has made its study critical to our understanding of various aspects of human health and disease.
Ashley S. Pitt, Susan K. Buchanan
doaj +4 more sources
Structural insights into assembly of human mitochondrial translocase TOM complex [PDF]
Cell Discovery, 2021 Zeyuan Guan +7 more
doaj +5 more sources
TOM complex‐independent transport pathway of myoglobin into mitochondria in C2C12 myotubes [PDF]
Physiological Reports, 2023 Recently, we found that myoglobin (Mb) localizes in both the cytosol and mitochondrial intermembrane space in rodent skeletal muscle. Most proteins of the intermembrane space pass through the outer mitochondrial membrane via the translocase of the outer ...
Rikuhide Koma +6 more
doaj +2 more sources
The Oglakhty-Tom Petroglyphs of the Lower Tom Rock Art Complex
Вестник Кемеровского государственного университета, 2021 The present research featured the cultural and chronological context of the Oglakhty-Tom petroglyphs found in the lower valley of the Tom river. The author compiled a complete list of geometric petroglyphs of South Siberia, as well as a series of ...
I. V. Kovtun
doaj +3 more sources
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system. [PDF]
Sci Adv, 2023 Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-onset Parkinson’s disease (PD). Stabilization of PINK1 at the translocase of outer membrane (TOM) complex of damaged mitochondria is critical for its activation. The mechanism of how PINK1 is activated in the TOM complex is unclear.
Raimi OG +14 more
europepmc +8 more sources
Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM [PDF]
IUCrJMost mitochondrial precursor proteins are encoded in the cell nucleus and synthesized on cytoplasmic ribosomes. The translocase of the outer membrane (TOM) is the main protein-import pore of mitochondria, recognizing nascent precursors of mitochondrially
Agalya Periasamy +7 more
doaj +2 more sources
Recognition of preproteins by the isolated TOM complex of mitochondria [PDF]
EMBO Journal, 2000 A multisubunit complex in the mitochondrial outer membrane, the TOM complex, mediates targeting and membrane translocation of nuclear-encoded preproteins. We have isolated the TOM holo complex, containing the preprotein receptor components Tom70 and Tom20, and the TOM core complex, which lacks these receptors.
Doron Rapaport, Stephan Nußberger
exaly +3 more sources
New insights into the structure and dynamics of the TOM complex in mitochondria. [PDF]
Biochem Soc TransTo date, there is no general physical model of the mechanism by which unfolded polypeptide chains with different properties are imported into the mitochondria. At the molecular level, it is still unclear how transit polypeptides approach, are captured by the protein translocation machinery in the outer mitochondrial membrane, and how they subsequently ...
Nussberger S, Ghosh R, Wang S.
europepmc +3 more sources
Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis. [PDF]
PLoS Biology, 2019 Mitochondria originated from proteobacterial endosymbionts, and their transition to organelles was tightly linked to establishment of the protein import pathways.
Abhijith Makki +8 more
doaj +2 more sources
Mim1, a protein required for the assembly of the TOM complex of mitochondria [PDF]
EMBO Reports, 2005 The translocase of the outer mitochondrial membrane (TOM complex) is the general entry site for newly synthesized proteins into mitochondria. This complex is essential for the formation and maintenance of mitochondria. Here, we report on the role of the integral outer membrane protein, Mim1 (mitochondrial import), in the biogenesis of mitochondria ...
Doron Rapaport, Thomas Waizenegger
exaly +3 more sources