Results 41 to 50 of about 5,833,753 (257)
In vivo analysis of conserved C. elegans tomosyn domains. [PDF]
PLoS ONE, 2011 Neurosecretion is critically dependent on the assembly of a macromolecular complex between the SNARE proteins syntaxin, SNAP-25 and synaptobrevin. Evidence indicates that the binding of tomosyn to syntaxin and SNAP-25 interferes with this assembly ...
Anna O Burdina +4 more
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A Brain-Inspired Theory of Mind Spiking Neural Network for Reducing Safety Risks of Other Agents
Frontiers in Neuroscience, 2022 Artificial Intelligence (AI) systems are increasingly applied to complex tasks that involve interaction with multiple agents. Such interaction-based systems can lead to safety risks.
Zhuoya Zhao +9 more
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HeliyonIndividuals with schizophrenia have difficulty attributing mental states to themselves and to others - Theory of Mind (ToM). ToM is a complex, multifaceted theoretical construct comprising first and second order, first and third person, egocentric and ...
Francesca Marina Bosco +3 more
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Frontiers in Psychiatry, 2020 Theory of mind (ToM) or mentalizing difficulties is reported in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), but the mechanism underpinning these apparently shared deficits is relatively unknown.
Daniel Ilzarbe +15 more
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The Mitochondrial Routing of the Kv1.3 Channel
Frontiers in Oncology, 2022 Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes.
Jesusa Capera +5 more
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Dynamics of the TOM Complex of Mitochondria during Binding and Translocation of Preproteins [PDF]
Molecular and Cellular Biology, 1998 Translocation of preproteins across the mitochondrial outer membrane is mediated by the TOM complex. This complex consists of receptor components for the initial contact with preproteins at the mitochondrial surface and membrane-embedded proteins which promote transport and form the translocation pore.
D, Rapaport +6 more
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The selectivity filter of the mitochondrial protein import machinery
BMC Biology, 2020 Background The uptake of newly synthesized nuclear-encoded mitochondrial proteins from the cytosol is mediated by a complex of mitochondrial outer membrane proteins comprising a central pore-forming component and associated receptor proteins.
Sebastian Kreimendahl +4 more
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Dissecting the interactions of PINK1 with the TOM complex in depolarized mitochondria [PDF]
, 2022 Abstract Mitochondria dysfunction is involved in the pathomechanism of many illnesses including Parkinson’s disease. PINK1, which is mutated in some cases of familiar Parkinsonism, is a key component in the degradation of damaged mitochondria by mitophagy.
Klaudia K. Maruszczak +4 more
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Theory of mind on demand: do we prepare or react?
Frontiers in PsychologyReasoning about others’ thoughts, emotions, or intentions is a sophisticated human ability. Modelling such a complex phenomenon with limited available resources is a challenging pursuit. This work proposes the hypothesis of demand-driven and reactive ToM
Marion Roth, Stacy Marsella
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Unclogging of the TOM complex under import stress
Biological ChemistryAbstract Mitochondrial functions and biogenesis depend on the import of more than 1,000 proteins which are synthesized as precursor proteins on cytosolic ribosomes. Mitochondrial protein translocases sort the precursor proteins into the mitochondrial sub-compartments: outer and inner membrane, the intermembrane space and the matrix.
Joshua Jackson, Thomas Becker
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