Two conformations of the Tom20 preprotein receptor in the TOM holo complex
Proceedings of the National Academy of Sciences of the United States of America, 2023 The TOM complex is the main entry point for precursor proteins (preproteins) into mitochondria. Preproteins containing targeting sequences are recognized by the TOM complex and imported into mitochondria. We have determined the structure of the TOM core complex from Neurospora crassa by ...
Nina Morgner +2 more
exaly +4 more sources
Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22·54 complex [PDF]
EMBO Journal, 1999 Members of the mitochondrial carrier family such as the ADP/ATP carrier (AAC) are composed of three structurally related modules. Here we show that each of the modules contains a mitochondrial import signal recognized by Tim10 and Tim12 in the intermembrane space.
Walter Neupert
exaly +3 more sources
Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. [PDF]
Proc Natl Acad Sci U S A, 2022 Su J +7 more
europepmc +2 more sources
From executive control to social emotions: mediation analysis of theory of mind linking executive functions to envy but not Schadenfreude [PDF]
BMC PsychologyBackground Complex social emotions such as envy and Schadenfreude require the integration of high-level cognitive processes, particularly Executive Functions (EFs) and Theory of Mind (ToM).
Daniel Franco-O´Byrne +2 more
doaj +2 more sources
Theory of mind variability in schizophrenia: A neurodevelopmental perspective through neurological soft signs and premorbid adjustment [PDF]
Schizophrenia Research: CognitionBackground: Theory of Mind (ToM) is impaired in individuals with schizophrenia (SZ). Given the neurodevelopmental nature of both social cognition and SZ, variations in ToM abilities likely originate early in life.
M. Giralt-López +9 more
doaj +2 more sources
The TOM complex from an evolutionary perspective and the functions of TOMM70
Biological ChemistryAbstract In humans, up to 1,500 mitochondrial precursor proteins are synthesized at cytosolic ribosomes and must be imported into the organelle. This is not only essential for mitochondrial but also for many cytosolic functions. The majority of mitochondrial precursor proteins are imported over the translocase of the outer membrane (TOM).
Sven Dennerlein
exaly +4 more sources
Atomic structure of human TOM core complex [PDF]
Cell Discovery, 2020 AbstractThe translocase of the outer mitochondrial membrane (TOM) complex is the main entry gate for mitochondrial precursor proteins synthesized on cytosolic ribosomes. Here we report the single-particle cryo-electron microscopy (cryo-EM) structure of the dimeric human TOM core complex (TOM-CC).
Wenhe Wang +8 more
openaire +2 more sources
From TOM to the TIM23 complex – handing over of a precursor [PDF]
Biological Chemistry, 2020 Abstract Mitochondrial precursor proteins with amino-terminal presequences are imported via the presequence pathway, utilizing the TIM23 complex for inner membrane translocation. Initially, the precursors pass the outer membrane through the TOM complex and are handed over to the TIM23 complex where they are sorted into the inner membrane
Sylvie Callegari +2 more
openaire +5 more sources
Mapping protein interactions in the active TOM-TIM23 supercomplex
Nature Communications, 2021 The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and the ...
Ridhima Gomkale +13 more
doaj +1 more source