Results 201 to 210 of about 4,850,535 (301)

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Copper, cuproptosis, and cancer: biology concepts of a novel cell death. [PDF]

Apoptosis
Eshraghi R, Hosseini N, Yazdani MS, Badihi S, Pirmoradian P, Bahrami A, Darouei B, Ghanouni S, Lam AK, Hamblin MR.   +9 more
europepmc   +1 more source

Posttranslational transport of proteins in the assembly of mitochondrial membranes

, 1980
Neher, Eva-Maria, Harmey, Matthew A., Hennig, Bernd, Zimmermann, Richard, Neupert, Walter   +4 more
openaire   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Post-translational protein S-palmitoylation in renal tubular injury: mechanisms and therapeutic implications. [PDF]

Front Cell Dev Biol
Li M, Zhu H, Zhao H, Liu C, Wang Y, Zuo L.   +5 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Alkylamidobetaines Induced Changes in Multidrug-Resistant, Biofilming <i>Candida</i><i>glabrata</i>-Analysis of Oxidative Stress and Cellular Proteome. [PDF]

Int J Mol Sci
Bromke MA, Nowak E, Bortkiewicz O, Poniewierka B, Gleńsk M, Nawrot U, Luzarowski M, Widelski J, Lamch Ł, Wilk KA, Paluch E.   +10 more
europepmc   +1 more source

2SA2-01 Mitochondrial translocators that mediate sorting of 1000 different mitochondrial proteins(2SA2 Research frontiers of protein transport across the membrane,The 47th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri, 2009
Koji Yamano, Toshiya Endo
openaire   +2 more sources

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Mitochondrial molecular diversity in the brain. [PDF]

Curr Opin Neurobiol
Sainz AG, Wang X.
europepmc   +1 more source