Results 41 to 50 of about 419,034 (232)
Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy?
EMBO Molecular Medicine, 2014 Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being ...
Robert N Lightowlers +1 more
doaj +1 more source
MYOPATHY AS A DESTABILIZING FACTOR OF MEAT QUALITY FORMATION
Теория и практика переработки мяса, 2019 This review paper is devoted to myopathy of slaughter animals and poultry, and examines a relationship between fast growth of muscle tissue in hybrid pigs, broiler chickens and turkey, and high frequency of detection of spontaneous or idiopathic ...
Anastasiia A. Semenova +4 more
doaj +1 more source
Advanced Science, EarlyView.Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu +18 more
wiley +1 more source
Chronic pneumopathy secondary to swallowing disorder in a patient with mitochondrial myopathy
Iatreia, 2019 Introduction: Chronic lung disease secondary to dysphagia is a frequent complication in patients with neuromuscular diseases. Mitochondrial myopathies could lead to progressive lung damage due to chronic aspiration syndrome. Clinical case: Seven-year-
Palacio Petri, Silvia +2 more
doaj +1 more source
Myogenic Cell Transplantation in Genetic and Acquired Diseases of Skeletal Muscle
Frontiers in Genetics, 2021 This article will review myogenic cell transplantation for congenital and acquired diseases of skeletal muscle. There are already a number of excellent reviews on this topic, but they are mostly focused on a specific disease, muscular dystrophies and in ...
Olivier Boyer +40 more
doaj +1 more source
Advanced Science, EarlyView.Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo +5 more
wiley +1 more source
Potassium dependent rescue of a myopathy with core-like structures in mouse
eLife, 2015 Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous animals
M Gartz Hanson +4 more
doaj +1 more source
Advanced Science, EarlyView.HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng +10 more
wiley +1 more source
Oxidative stress, mitochondrial dysfunction, and respiratory chain enzyme defects in inflammatory myopathies [PDF]
, 2023 We investigated the relationship between oxidative stress and inflammatory myopathies. We searched in the current literature the role of mitochondria and respiratory chain defects as sources of oxidative stress and reactive oxygen species production that
Danieli, Maria Giovanna +11 more
core +1 more source
Autophagy in muscle regeneration: potential therapies for myopathies
Journal of Cachexia, Sarcopenia and Muscle, 2022 Autophagy classically functions as a physiological process to degrade cytoplasmic components, protein aggregates, and/or organelles, as a mechanism for nutrient breakdown, and as a regulator of cellular architecture.
Wei Chen +3 more
doaj +1 more source