Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia–Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset [PDF]
MusclesPeripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia–reperfusion (IR) settings, but whether PDE 4 inhibition protects skeletal muscle ...
Anne-Laure Charles +8 more
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Mitochondria-Targeted Antioxidants and Skeletal Muscle Function [PDF]
Antioxidants, 2018 One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting
Sophie C. Broome +2 more
doaj +5 more sources
Mitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass [PDF]
AntioxidantsMechanical unloading of skeletal muscle triggers various signaling alterations that result in muscle atrophy and weakness. Mitochondria are essential to muscle health, acting not only as energy suppliers but also as central mediators of molecular ...
Kristina A. Sharlo +2 more
doaj +2 more sources
Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia [PDF]
MedCommWhile thrombolytic therapy can be effective for stroke, many patients are unable to benefit due to time restrictions. In an aging society, sarcopenia, a condition marked by reduced muscle volume, often worsens recovery after stroke.
Toshiki Inaba +8 more
doaj +2 more sources
Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +6 more
doaj +1 more source
Cardiorenal Syndrome: Ebony and Ivory
Diagnostics, 2023 The kidney and cardiovascular systems are closely interconnected and interact continuously in both physiological and pathological conditions [...]
Nans Florens
doaj +1 more source
Statins, Muscle Disease and Mitochondria [PDF]
Journal of Clinical Medicine, 2017 Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure is predicted to rise to >23 million by 2030. Numerous studies have explored the relationship between cholesterol and CVD and there is now consensus that dyslipidaemia is a causal factor in the pathogenesis of atherosclerosis.
Ramachandran, Radha +1 more
openaire +2 more sources
Mitochondrial Properties in Skeletal Muscle Fiber
Cells, 2023 Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements.
Han Dong, Shih-Yin Tsai
doaj +1 more source
The Role of Mitochondria in Mediation of Skeletal Muscle Repair
Muscles, 2023 Musculoskeletal health is directly linked to independence and longevity, but disease and aging impairs muscle mass and health. Complete repair after a pathological or physiological muscle injury is critical for maintaining muscle function, yet muscle ...
Stephen E. Alway +2 more
doaj +1 more source
Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]
, 2011 Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Alexei Vazquez, Zoltán N. Oltvai
core +7 more sources