Results 11 to 20 of about 1,131,582 (303)
Mitochondria-Targeted Antioxidants and Skeletal Muscle Function [PDF]
Antioxidants, 2018 One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting
Sophie C. Broome +2 more
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Nature Communications, 2021 Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both ...
Jerome Avellaneda +6 more
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Characterization of frog muscle mitochondria
American Journal of Physiology-Cell Physiology, 1978 Studies on oxidative phosphorylation revealed that, in frog skeletal muscle mitochondria (SKMM) from the thigh, the adenosine diphosphate/oxygen ratio (ADP/O) was 2.8 +/- 0.1 SE, and the respiratory control ratio was 9.5 +/- 0.9, with pyruvate/malate as ...
U. Kromer +4 more
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Pathology of mitochondria in MELAS syndrome: an ultrastructural study
Polish Journal of Pathology, 2017 Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented.
Paulina Felczak +8 more
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Statins, Muscle Disease and Mitochondria [PDF]
Journal of Clinical Medicine, 2017 Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure is predicted to rise to >23 million by 2030. Numerous studies have explored the relationship between cholesterol and CVD and there is now consensus that dyslipidaemia is a causal factor in the pathogenesis of atherosclerosis.
Ramachandran, Radha +1 more
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Vitamin D, Mitochondria, and Muscle [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2013 Vitamin D was initially identified as the cure for rickets. Its metabolism and its action on bone and growth plate are now well recognized. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D) probably has, however, a much wider spectrum of activities because the vitamin D receptor (VDR) is expressed in virtually all nucleated cells, the activating CYP27B1 or 1 ...
Roger, Bouillon, Annemieke, Verstuyf
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Response of Skeletal Muscle Mitochondria to Hypoxia [PDF]
Experimental Physiology, 2003 This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long‐term exposure to severe environmental hypoxia decreases ...
Hoppeler, Hans +3 more
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THE MITOCHONDRIA OF INSECT FLIGHT MUSCLE [PDF]
Journal of Histochemistry & Cytochemistry, 1953 It has been known for over a century that the ifight muscles of insects belonging to the two orders Diptera (the true ffies), and Hymenoptera (ants, bees and wasps) are specialized in certain aspects of their morphology to a degree not found in other groups of insects.
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Skeletal Muscle Mitochondria and Aging: A Review [PDF]
Journal of Aging Research, 2012 Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines in skeletal muscle mitochondria are thought to play a primary role in this process. Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched.
Courtney M. Peterson +2 more
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Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]
, 2011 Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Vazquez, Alexei +8 more
core +2 more sources