Results 11 to 20 of about 155,819 (265)
Mitochondria-Targeted Antioxidants and Skeletal Muscle Function [PDF]
Antioxidants, 2018 One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting
Sophie C. Broome +2 more
doaj +5 more sources
Statins, Muscle Disease and Mitochondria [PDF]
Journal of Clinical Medicine, 2017 Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure is predicted to rise to >23 million by 2030. Numerous studies have explored the relationship between cholesterol and CVD and there is now consensus that dyslipidaemia is a causal factor in the pathogenesis of atherosclerosis.
Ramachandran, Radha +1 more
openaire +2 more sources
Vitamin D, Mitochondria, and Muscle [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2013 Vitamin D was initially identified as the cure for rickets. Its metabolism and its action on bone and growth plate are now well recognized. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D) probably has, however, a much wider spectrum of activities because the vitamin D receptor (VDR) is expressed in virtually all nucleated cells, the activating CYP27B1 or 1 ...
Roger, Bouillon, Annemieke, Verstuyf
openaire +2 more sources
Response of Skeletal Muscle Mitochondria to Hypoxia [PDF]
Experimental Physiology, 2003 This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long‐term exposure to severe environmental hypoxia decreases ...
Hoppeler, Hans +3 more
openaire +3 more sources
THE MITOCHONDRIA OF INSECT FLIGHT MUSCLE [PDF]
Journal of Histochemistry & Cytochemistry, 1953 It has been known for over a century that the ifight muscles of insects belonging to the two orders Diptera (the true ffies), and Hymenoptera (ants, bees and wasps) are specialized in certain aspects of their morphology to a degree not found in other groups of insects.
openaire +2 more sources
Skeletal Muscle Mitochondria and Aging: A Review [PDF]
Journal of Aging Research, 2012 Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines in skeletal muscle mitochondria are thought to play a primary role in this process. Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched.
Courtney M. Peterson +2 more
openaire +3 more sources
MusclesPeripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia–reperfusion (IR) settings, but whether PDE 4 inhibition protects skeletal muscle ...
Anne-Laure Charles +8 more
doaj +1 more source
The Journal of Poultry Science, 2018 Mitochondrial content is regarded a useful feature to distinguish muscle-fiber types in terms of energy metabolism in skeletal muscles. Increasing evidence suggests that specific mitochondrial bioenergetic phenotypes exist in metabolically different ...
Yuki Hakamata +4 more
doaj +1 more source
Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle. [PDF]
PLoS ONE, 2014 In most cells, mitochondria are highly dynamic organelles that constantly fuse, divide and move. These processes allow mitochondria to redistribute in a cell and exchange contents among the mitochondrial population, and subsequently repair damaged ...
Ruohai Liu +6 more
doaj +1 more source
BiologyThe anti-inflammatory and analgesic properties of cannabis might be useful to treat muscle diseases, including those linked or not to alcohol. Nevertheless, delta 9 tetrahydrocannabinol (THC) and ethanol (EtOH), often used concomitantly, can have ...
Anne-Laure Charles +8 more
doaj +1 more source