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Glutathionylation of Mitochondrial Proteins
Antioxidants & Redox Signaling, 2005Many proteins contain free thiols that can be modified by the reversible formation of mixed disulfides with low-molecular-weight thiols through a process called S-thiolation. As the majority of these modifications result from the interaction of protein thiols with the endogenous glutathione pool, protein glutathionylation is the predominant alteration.
Thomas R, Hurd +6 more
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Tissue-specific mitochondrial proteins
Biochimie, 1989Mitochondrial proteins from rat brain cortex, muscle, liver, and from neuronal cells in culture were compared on 2-D electrophoregrams. This analysis permitted characterization of certain specificities in the distribution of polypeptides depending on tissue localization.
J L, Vayssiere +4 more
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Mitochondrial biogenesis: Inhibitors of mitochondrial protein synthesis
Molecular and Cellular Biochemistry, 1977The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and ...
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Synthesis of Mitochondrial Proteins
1973The recent discovery that the ubiquitous energy-transducing organelle of eukaryotic cells, the mitochondrion, contains its own DNA, distinct from that of the nucleus (for recent reviews, see 1-4), has generated intensive investigations in a number of related areas.
K, Dawidowicz, H R, Mahler
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Mitochondrial protein tyrosine nitration
Free Radical Research, 2010Mitochondria are primary loci for the intracellular formation and reactions of reactive oxygen and nitrogen species including superoxide (O₂•⁻), hydrogen peroxide (H₂O₂) and peroxynitrite (ONOO⁻). Depending on formation rates and steady-state levels, the mitochondrial-derived short-lived reactive species contribute to signalling events and/or ...
Laura, Castro +3 more
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Mammalian mitochondrial uncoupling proteins
The International Journal of Biochemistry & Cell Biology, 1998The mammalian uncoupling protein (UCP-1) from the gene family of mitochondrial carriers is a dimer of identical 33 kDa subunits, each containing six membrane-spanning alpha-helices. Its expression, restricted to brown fat, occurs upon birth, cold acclimation and overfeeding. UCP-1 dissipates redox energy and thereby provides heat to the animal.
P, Jezek, K D, Garlid
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Mitochondrial diseases caused by dysfunctional mitochondrial protein import
Biochemical Society Transactions, 2018Mitochondria are essential organelles which perform complex and varied functions within eukaryotic cells. Maintenance of mitochondrial health and functionality is thus a key cellular priority and relies on the organelle's extensive proteome. The mitochondrial proteome is largely encoded by nuclear genes, and mitochondrial proteins must be sorted to the
Thomas Daniel, Jackson +2 more
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Mitochondrial protein import stress
Nature Cell BiologyMitochondria have to import a large number of precursor proteins from the cytosol. Chaperones keep these proteins in a largely unfolded state and guide them to the mitochondrial import sites. Premature folding, mitochondrial stress and import defects can cause clogging of import sites and accumulation of non-imported precursors, representing a critical
Nikolaus Pfanner +2 more
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Linking mitochondrial dynamics to mitochondrial protein quality control
Current Opinion in Genetics & Development, 2016Over the last decade, countless discoveries have been made that have expanded our knowledge of mitochondrial biology, and more often than not, these discoveries provided fascinating new insights into the etiology of human disease. For example, advances in mitochondrial genetics exposed the role of mitochondrial mutations in cancer progression, and the ...
Suraiya, Haroon, Marc, Vermulst
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Mitochondrial Membrane Protein–Associated Neurodegeneration
Pediatric Neurology, 2015[No abstract available]
Sanem Yilmaz +2 more
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