Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide
Frontiers in Medicine, 2018 The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed—(1) a depot
Anatoly N. Osipov +5 more
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Polypeptides traverse the mitochondrial envelope in an extended state [PDF]
, 1990 Most mitochondrial proteins are synthesized as precursors in the cytosol and imported through the contact sites between outer and inner mitochondrial membranes.
Guiard, Bernard +4 more
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Frontiers in Physiology, 2022 The vast majority of mitochondrial proteins are encoded in the nuclear genome and synthesized on cytosolic ribosomes as precursor proteins with specific mitochondrial targeting signals. Mitochondrial targeting signals are very diverse, however, about 70%
Marcel G. Genge, Dejana Mokranjac
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Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]
, 1994 Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Craig, Elisabeth A. +3 more
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Mitochondrial ribosome assembly in Neurospora. Structural analysis of mature and partially assembled ribosomal subunits by equilibrium centrifugation in CsCl gradients [PDF]
, 1982 In Neurospora, one protein associated with the mitochondrial small ribosomal subunit (S-5, Mr 52,000) is synthesized intramitochondrially and is assumed to be encoded by mtDNA.
Lambowitz, Alan M., LaPolla, Robert J.
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MitProNet: A knowledgebase and analysis platform of proteome, interactome and diseases for mammalian mitochondria. [PDF]
PLoS ONE, 2014 Mitochondrion plays a central role in diverse biological processes in most eukaryotes, and its dysfunctions are critically involved in a large number of diseases and the aging process.
Jiabin Wang +8 more
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Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin
Frontiers in Physiology, 2020 Mitochondrial dysfunction is a hallmark of cardiac pathophysiology. Defects in mitochondrial performance disrupt contractile function, overwhelm myocytes with reactive oxygen species (ROS), and transform these cellular powerhouses into pro-death ...
Justin M. Quiles, Åsa B. Gustafsson
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Integrative identification of Arabidopsis mitochondrial proteome and its function exploitation through protein interaction network. [PDF]
PLoS ONE, 2011 Mitochondria are major players on the production of energy, and host several key reactions involved in basic metabolism and biosynthesis of essential molecules.
Jian Cui +3 more
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PLoS Biology, 2021 Defects in mitochondrial function activate compensatory responses in the cell. Mitochondrial stress that is caused by unfolded proteins inside the organelle induces a transcriptional response (termed the "mitochondrial unfolded protein response" [UPRmt])
Maria Sladowska +8 more
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Transport of proteins across mitochondrial membranes [PDF]
, 1994 The vast majority of proteins comprising the mitochondrion are encoded by nuclear genes, synthesized on ribosomes in the cytosol, and translocated into the various mitochondrial subcompartments. During this process proteins must cross the lipid membranes
Neupert, Walter
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