Results 31 to 40 of about 598,960 (261)

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]

open access: yesNucleic Acids Research, 2012
Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J   +11 more
openaire   +3 more sources

THE MITOCHONDRIAL PROTEIN IMPORT APPARATUS [PDF]

open access: yesAnnual Review of Biochemistry, 1990
INTRODUCTION .. . . 331 THE PRECURSOR PROTEINS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332 Targeting Signals 332 Translocation Competence 335 IMPORT RECEPTORS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . .
Pfanner, Nikolaus, Neupert, Walter
openaire   +4 more sources

Mitochondrial carrier proteins [PDF]

open access: yesFEBS Letters, 1994
Ten mitochondrial carriers have been purified from animal mitochondria. They are small proteins with a molecular mass ranging from 28 to 34 kDa on SDS‐PAGE. So far, five of these proteins have been sequenced. Their polypeptide chain consists of three tandemly related sequences of about 100 amino acids.
openaire   +2 more sources

Sorting of exclusive mitochondrial proteins from the Mitoproteome database

open access: yesBulletin of the National Research Centre, 2022
World Wide Web and scientific literature record information regarding several organelles and mitochondria is not an exception. However, currently mitochondrial databases also provide information about non-mitochondrial proteins.
Deepak Yadav   +5 more
doaj   +1 more source

Shexiang Baoxin Pill Corrects Metabolic Disorders in a Rat Model of Metabolic Syndrome by Targeting Mitochondria

open access: yesFrontiers in Pharmacology, 2018
Background: Metabolic syndrome (MS) is a global epidemic that has great socioeconomic and public health implications. This study reports observed effects of the Shexiang Baoxin Pill (SBP) in a rat model of MS and explores its underlying mechanisms of ...
Dan Wei   +5 more
doaj   +1 more source

Dual targeted mitochondrial proteins are characterized by lower MTS parameters and total net charge. [PDF]

open access: yesPLoS ONE, 2008
BACKGROUND: In eukaryotic cells, identical proteins can be located in different subcellular compartments (termed dual-targeted proteins). METHODOLOGY/PRINCIPAL FINDINGS: We divided a reference set of mitochondrial proteins (published single gene studies)
Maya Dinur-Mills, Merav Tal, Ophry Pines
doaj   +1 more source

Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1

open access: yesFrontiers in Physiology, 2022
Mitochondria contain their own DNA, mitochondrial DNA, which encodes thirteen proteins. However, mitochondria require thousands of proteins encoded in the nucleus to carry out their many functions.
Aditya Sen, Aditya Sen, Rachel T. Cox
doaj   +1 more source

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

open access: yesOpen Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski   +2 more
doaj   +1 more source

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

open access: yesCell Reports, 2023
Summary: In mammals, about 99% of mitochondrial proteins are synthesized in the cytosol as precursors that are subsequently imported into the organelle. The mitochondrial health and functions rely on an accurate quality control of these imported proteins.
Julie Lavie   +11 more
doaj   +1 more source

Minocycline impedes mitochondrial-dependent cell death and stabilizes expression of hypoxia inducible factor-1α in spinal cord injury

open access: yesArchives of Medical Science, 2019
Introduction One of the crucial mechanisms following spinal cord injury is mitochondria-associated cell death. Minocycline, an anti-inflammatory drug, is well known to impede mitochondrial cell death.
Guolei Zhang   +3 more
doaj   +1 more source

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