Results 41 to 50 of about 910,991 (300)
Generation of a mitochondrial protein compendium in Dictyostelium discoideum
iScience, 2022 Summary: The social ameba Dictyostelium discoideum has emerged as a powerful model to study mitochondrial genetics and bioenergetics. However, a comprehensive inventory of mitochondrial proteins that is critical to understanding mitochondrial processes ...
Anna V. Freitas +6 more
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Targeting and Insertion of Membrane Proteins in Mitochondria
Frontiers in Cell and Developmental Biology, 2021 Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
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Biogenesis of mitochondrial porin [PDF]
, 1990 We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann +74 more
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Frontiers in Pharmacology, 2018 Background: Metabolic syndrome (MS) is a global epidemic that has great socioeconomic and public health implications. This study reports observed effects of the Shexiang Baoxin Pill (SBP) in a rat model of MS and explores its underlying mechanisms of ...
Dan Wei +5 more
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Players in Mitochondrial Dynamics and Female Reproduction
Frontiers in Molecular Biosciences, 2021 Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control.
Weiwei Zou +12 more
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Restricted mitochondrial protein acetylation initiates mitochondrial autophagy [PDF]
Journal of Cell Science, 2013 As nutrient-sensing nuclear/cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy. Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators.
Bradley R, Webster +14 more
openaire +2 more sources
Frontiers in Physiology, 2022 The vast majority of mitochondrial proteins are encoded in the nuclear genome and synthesized on cytosolic ribosomes as precursor proteins with specific mitochondrial targeting signals. Mitochondrial targeting signals are very diverse, however, about 70%
Marcel G. Genge, Dejana Mokranjac
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Archives of Medical Science, 2019 Introduction One of the crucial mechanisms following spinal cord injury is mitochondria-associated cell death. Minocycline, an anti-inflammatory drug, is well known to impede mitochondrial cell death.
Guolei Zhang +3 more
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Frontiers in Cell and Developmental Biology, 2022 Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1,000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as ...
David R. L. Robinson +14 more
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