Results 41 to 50 of about 598,960 (261)

Mechanisms of Modulation of Mitochondrial Architecture

Biomolecules, 2023
Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles.
Juan Pablo Muñoz, Fernanda Luisa Basei, María Laura Rojas, David Galvis, Antonio Zorzano   +4 more
doaj   +1 more source

Generation of a mitochondrial protein compendium in Dictyostelium discoideum

iScience, 2022
Summary: The social ameba Dictyostelium discoideum has emerged as a powerful model to study mitochondrial genetics and bioenergetics. However, a comprehensive inventory of mitochondrial proteins that is critical to understanding mitochondrial processes ...
Anna V. Freitas, Jake T. Herb, Miao Pan, Yong Chen, Marjan Gucek, Tian Jin, Hong Xu   +6 more
doaj   +1 more source

Restricted mitochondrial protein acetylation initiates mitochondrial autophagy [PDF]

Journal of Cell Science, 2013
As nutrient-sensing nuclear/cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy. Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators.
Bradley R, Webster, Iain, Scott, Kim, Han, Jian H, Li, Zhongping, Lu, Mark V, Stevens, Daniela, Malide, Yong, Chen, Leigh, Samsel, Patricia S, Connelly, Mathew P, Daniels, J Philip, McCoy, Christian A, Combs, Marjan, Gucek, Michael N, Sack   +14 more
openaire   +2 more sources

Targeting and Insertion of Membrane Proteins in Mitochondria

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
doaj   +1 more source

Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide

Frontiers in Medicine, 2018
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed—(1) a depot
Anatoly N. Osipov, Tatiana V. Machneva, Evgeny A. Buravlev, Evgeny A. Buravlev, Yury A. Vladimirov, Yury A. Vladimirov   +5 more
doaj   +1 more source

Players in Mitochondrial Dynamics and Female Reproduction

Frontiers in Molecular Biosciences, 2021
Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control.
Weiwei Zou, Weiwei Zou, Weiwei Zou, Dongmei Ji, Dongmei Ji, Dongmei Ji, Zhiguo Zhang, Zhiguo Zhang, Zhiguo Zhang, Li Yang, Yunxia Cao, Yunxia Cao, Yunxia Cao   +12 more
doaj   +1 more source

Mitochondrial Protein Homeostasis and Cardiomyopathy

International Journal of Molecular Sciences, 2022
Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardiomyopathy is frequently unclear.
Emily Wachoski-Dark, Tian Zhao, Aneal Khan, Timothy E. Shutt, Steven C. Greenway   +4 more
openaire   +2 more sources

Biochemical and Proteomic Analyses in Drought-Tolerant Wheat Mutants Obtained by Gamma Irradiation

Plants
The bread wheat cultivar (Triticum aestivum L. cv. Sagittario) as a parental line and its mutant, drought-tolerant lines (Mutant lines 4 and 5) were subjected to polyethylene glycol (PEG)-induced drought.
Ayşe Şen, Tamer Gümüş, Aslıhan Temel, İrfan Öztürk, Özge Çelik   +4 more
doaj   +1 more source

Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain

Frontiers in Cell and Developmental Biology, 2022
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1,000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as ...
David R. L. Robinson, Daniella H. Hock, Linden Muellner-Wong, Linden Muellner-Wong, Roopasingam Kugapreethan, Boris Reljic, Boris Reljic, Elliot E. Surgenor, Elliot E. Surgenor, Carlos H. M. Rodrigues, Carlos H. M. Rodrigues, Nikeisha J. Caruana, Nikeisha J. Caruana, David A. Stroud, David A. Stroud   +14 more
doaj   +1 more source

Coordinated Translocation of Presequence-Containing Precursor Proteins Across Two Mitochondrial Membranes: Knowns and Unknowns of How TOM and TIM23 Complexes Cooperate With Each Other

Frontiers in Physiology, 2022
The vast majority of mitochondrial proteins are encoded in the nuclear genome and synthesized on cytosolic ribosomes as precursor proteins with specific mitochondrial targeting signals. Mitochondrial targeting signals are very diverse, however, about 70%
Marcel G. Genge, Dejana Mokranjac
doaj   +1 more source