Results 21 to 30 of about 2,483,935 (295)
RNAi-based gene silencing in primary mouse and human adipose tissues
Journal of Lipid Research, 2007 Cultured adipocyte cell lines are a model system widely used to study adipose function, but they exhibit significant physiological differences compared with primary cells from adipose tissue.
Vishwajeet Puri +8 more
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Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
eLife, 2022 Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu +5 more
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Mitochondrial carrier proteins [PDF]
FEBS Letters, 1994 Ten mitochondrial carriers have been purified from animal mitochondria. They are small proteins with a molecular mass ranging from 28 to 34 kDa on SDS‐PAGE. So far, five of these proteins have been sequenced. Their polypeptide chain consists of three tandemly related sequences of about 100 amino acids.
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Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]
Nucleic Acids Research, 2012 Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J +11 more
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MOM19, an import receptor for mitochondrial precursor proteins [PDF]
, 1989 We have identified a 19 kd protein of the mitochondrial outer membrane (MOM19). Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin ...
Söllner, Thomas +4 more
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ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
Life Science Alliance, 2021 The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Tianyao Xiao +2 more
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THE MITOCHONDRIAL PROTEIN IMPORT APPARATUS [PDF]
Annual Review of Biochemistry, 1990 INTRODUCTION .. . . 331 THE PRECURSOR PROTEINS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332 Targeting Signals 332 Translocation Competence 335 IMPORT RECEPTORS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . .
Pfanner, Nikolaus, Neupert, Walter
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Hsp70 in mitochondrial biogenesis [PDF]
, 1994 The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
Stuart, Rosemary A. +2 more
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A morphological view on mitochondrial protein targeting [PDF]
, 1994 Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ida J. van der Klei +5 more
core +1 more source
Frontiers in Pharmacology, 2018 Background: Metabolic syndrome (MS) is a global epidemic that has great socioeconomic and public health implications. This study reports observed effects of the Shexiang Baoxin Pill (SBP) in a rat model of MS and explores its underlying mechanisms of ...
Dan Wei +5 more
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