Results 11 to 20 of about 598,960 (261)

Mitochondrial Proteins as Exosomal Cargo: New Breast Cancer Biomarkers & Crucial Players in Carcinogenesis? [PDF]

Molecules
Mitochondrial proteins (mtPs) packaged into extracellular vesicles (EVs), particularly exosomes, have emerged as promising biomarkers and functional mediators in cancer biology.
Aleksei Shefer, Lyudmila Yanshole, Alina Grygor’eva, Natalia Yunusova, Irina Kondakova, Liudmila Spirina, Andrey Shevela, Alyona Chernyshova, Alexander Romanov, Svetlana Tamkovich   +9 more
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases [PDF]

Brain and Behavior
Background Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities
Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu   +10 more
doaj   +2 more sources

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis [PDF]

Frontiers in Pharmacology
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring in type 1 diabetes (T1D) but also seen in type 2 diabetes (T2D).
Ruiqiang Xie, Hongyan Xie, Hong Gao, Chunguang Xie, Haipo Yuan, Zhijun Feng   +5 more
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Mitochondrial proteins: Potential pathophysiological mechanisms of malignant progression in HCC. [PDF]

PLoS ONE
ObjectiveBased on the special role of mitochondria in tumour energy metabolism. We hope to explore the pathogenesis and potential therapeutic targets of Hepatocellular carcinoma by analysing the expression of 1136 mitochondrial proteins in hepatocellular
Yicun Liu, Yawen Shao, Xudong Zhu, Zhouming Shen, Zhaolian Bian   +4 more
doaj   +2 more sources

Mitochondrial ribosomal proteins: Candidate genes for mitochondrial disease [PDF]

Genetics in Medicine, 2004
Most of the energy requirement for cell growth, differentiation, and development is met by the mitochondria in the form of ATP produced by the process of oxidative phosphorylation. Human mitochondrial DNA encodes a total of 13 proteins, all of which are essential for oxidative phosphorylation.
Nathan Fischel-Ghodsian, Edward B Mougey, Thomas W O'Brien   +2 more
exaly   +3 more sources

Biogenesis of Mitochondrial Proteins [PDF]

Current Opinion in Cell Biology, 1989
Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
Tropschug, Maximilian, Neupert, Walter
  +7 more sources

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) [PDF]

Diabetes & Metabolism Journal, 2022
Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism.
Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim   +3 more
doaj   +1 more source

Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
openaire   +5 more sources

Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins

Biomolecules, 2022
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron–sulfur (Fe-S) clusters.
Francesca Camponeschi, Simone Ciofi-Baffoni, Vito Calderone, Lucia Banci   +3 more
doaj   +1 more source

The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses

Antioxidants, 2021
Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise.
Marisa L. Henry, Deborah Velez-Irizarry, Joe D. Pagan, Lorraine Sordillo, Jeff Gandy, Stephanie J. Valberg   +5 more
doaj   +1 more source