Results 11 to 20 of about 910,991 (300)

Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
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Biogenesis of Mitochondrial Proteins [PDF]

Biochemical Society Transactions, 1989
The majority of mitochondrial proteins are encoded by nuclear genes and are imported into the organelle after being synthesized on cytoplasmic ribosomes. During the last years our knowledge of the different stages of this import process of proteins into mitochondria has increased greatly.
Tropschug, Maximilian, Neupert, Walter
  +7 more sources

Sorting out mitochondrial proteins [PDF]

Trends in Cell Biology, 1993
Lill, Roland, Neupert, Walter, Stuart, Rosemary A.   +2 more
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Mitochondrial protein homeostasis [PDF]

IUBMB Life, 2013
AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova, Diana, Stojanovski, Agnieszka, Chacinska   +2 more
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Stress proteins and mitochondrial protein import [PDF]

Antonie van Leeuwenhoek, 1990
F-U Hartl, G Attardi, H Murakami, HRB Pelham, J Ostermann, J Rassow, JE Rothman, K Verner, M Schleyer, M Schwaiger, MY Cheng, N Pfanner, N Pfanner, N Pfanner, RJ Deshaies, RJ Ellis, SK Randall, W-J Chen, WT Wickner   +18 more
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Mitochondrial protein import [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of
Hartl, Franz-Ulrich, Pfanner, Nikolaus, Nicholson, Donald W., Neupert, Walter   +3 more
openaire   +4 more sources

The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses

Antioxidants, 2021
Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise.
Marisa L. Henry, Deborah Velez-Irizarry, Joe D. Pagan, Lorraine Sordillo, Jeff Gandy, Stephanie J. Valberg   +5 more
doaj   +1 more source

Mitochondrial protein dysfunction in pathogenesis of neurological diseases

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal ...
Liang Wang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Xiumei He, Xiumei He, Xiumei He, Shiming Pu, Shiming Pu, Shiming Pu, Cheng Yang, Cheng Yang, Cheng Yang, Qiong Wu, Qiong Wu, Qiong Wu, Zuping Zhou, Zuping Zhou, Xiaobo Cen, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao   +23 more
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Structural insight into mitochondrial β-barrel outer membrane protein biogenesis

Nature Communications, 2020
The Sorting and Assembly Machinery (SAM) complex folds beta-barrel proteins and inserts them into the mitochondrial outer membrane. Here authors report cryoEM structures of the SAM complex from Myceliophthora thermophila, which reveals a GST-like fold ...
Kathryn A. Diederichs, Xiaodan Ni, Sarah E. Rollauer, Istvan Botos, Xiaofeng Tan, Martin S. King, Edmund R. S. Kunji, Jiansen Jiang, Susan K. Buchanan   +8 more
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Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

eLife, 2022
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu, Catherine E Chang, Alexandra C Wooldredge, Benjamin Fong, Brian K Kennedy, Chuankai Zhou   +5 more
doaj   +1 more source