Results 61 to 70 of about 769,781 (230)

Transport of proteins across mitochondrial membranes [PDF]

, 1994
The vast majority of proteins comprising the mitochondrion are encoded by nuclear genes, synthesized on ribosomes in the cytosol, and translocated into the various mitochondrial subcompartments. During this process proteins must cross the lipid membranes
Neupert, Walter
core   +1 more source

Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin

Frontiers in Physiology, 2020
Mitochondrial dysfunction is a hallmark of cardiac pathophysiology. Defects in mitochondrial performance disrupt contractile function, overwhelm myocytes with reactive oxygen species (ROS), and transform these cellular powerhouses into pro-death ...
Justin M. Quiles, Åsa B. Gustafsson
doaj   +1 more source

Mitochondrial ribosomal proteins: Candidate genes for mitochondrial disease [PDF]

Genetics in Medicine, 2004
Most of the energy requirement for cell growth, differentiation, and development is met by the mitochondria in the form of ATP produced by the process of oxidative phosphorylation. Human mitochondrial DNA encodes a total of 13 proteins, all of which are essential for oxidative phosphorylation.
Edward B. Mougey, Thomas W. O'Brien, James E. Sylvester, Nathan Fischel-Ghodsian   +3 more
openaire   +3 more sources

Biogenesis of mitochondrial porin [PDF]

, 1990
We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann, A. L. Horwich, B. L. Geller, B. Schmidt, C. Smagula, C. Witte, C. Zwizinski, C. Zwizinski, D. M. Kolansky, D. Roise, D. Vestweber, D. W. Nicholson, E. C. Hurt, E. C. Hurt, E. C. Hurt, E. C. Hurt, F.-U. Hartl, G. Hallermayer, G. Hawlitschek, G. Heijne von, G. S. Adrian, H. Aquila, H. Aquila, H. Freitag, H. Freitag, H. Freitag, H. Murakami, H. Ono, H. Wiech, J. A. Rothblatt, K. Mihara, K. Mihara, L. Chen, M. Colombini, M. Eilers, M. Eilers, M. G. Waters, M. Linden, M. Mueckler, M. P. Yaffe, M. Schleyer, M. Schleyer, M. Schwaiger, M. Y. Cheng, M. Yang, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pflanner, R. A. Pollock, R. A. Stuart, R. Benz, R. E. Jensen, R. J. Deshaies, R. Jaenicke, R. Kleene, R. Kleene, R. Pfaller, R. Pfaller, R. Pfaller, R. Pfaller, R. Zimmermann, S. Hamajima, S. M. Gasser, S. M. Gasser, T. Hase, T. Imanaka, U. I. Flügge, W. Hansen, W. J. Chirico, W. Neupert, W.-J. Chen   +74 more
core   +1 more source

Restricted mitochondrial protein acetylation initiates mitochondrial autophagy [PDF]

Journal of Cell Science, 2013
As nutrient-sensing nuclear/cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy. Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators.
Mathew P. Daniels, Kim Han, Yong Chen, Michael N. Sack, Christian A. Combs, Jian H. Li, Zhongping Lu, J. Philip McCoy, Daniela Malide, Bradley R. Webster, Patricia S. Connelly, Mark V. Stevens, Iain Scott, Leigh Samsel, Marjan Gucek   +14 more
openaire   +2 more sources

Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]

Mol Cell Proteomics 12, 11 (2013) 3108-22, 2013
The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model. Both metallic copper and copper oxide nanoparticles have been tested, with copper ion and zirconium oxide nanoparticles used as controls.
arxiv   +1 more source

Targeting of the master receptor MOM19 to mitochondria [PDF]

, 1991
The targeting of proteins to mitochondria involves the recognition of the precursor proteins by receptors on the mitochondrial surface followed by insertion of the precursors into the outer membrane at the general insertion site GIP.
Dietmeier, Klaus A., Eckerskorn, Christoph, Lottspeich, Fritz, Neupert, Walter, Pfanner, Nikolaus, Schneider, Helmut, Söllner, Thomas, Trülzsch, Barbara   +7 more
core   +1 more source

Mitochondrial "Structural Protein"

Journal of Biological Chemistry, 1970
Abstract Two previously described preparations of bovine heart mitochondrial "structural protein" have been studied. Evidence is presented showing that both preparations are heterogeneous and contain two major components, one of which is derived from mitochondrial ATPase.
Alan E. Senior, David H. MacLennan
openaire   +3 more sources

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

Journal of Neuroinflammation, 2021
Background The lack of effective treatments for Alzheimer’s disease (AD) reflects an incomplete understanding of disease mechanisms. Alterations in proteins involved in mitochondrial dynamics, an essential process for mitochondrial integrity and function,
Andre F. Batista, Tayná Rody, Leticia Forny-Germano, Suzana Cerdeiro, Maria Bellio, Sergio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice   +7 more
doaj   +1 more source

Binding of the immunomodulatory drug Bz-423 to mitochondrial FoF1-ATP synthase in living cells by FRET acceptor photobleaching [PDF]

, 2016
Bz-423 is a promising new drug for treatment of autoimmune diseases. This small molecule binds to subunit OSCP of the mitochondrial enzyme FoF1-ATP synthase and modulates its catalytic activities. We investigate the binding of Bz-423 to mitochondria in living cells and how subunit rotation in FoF1-ATP synthase, i.e.
arxiv   +1 more source