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Measurement of Mitochondrial Respiration in Platelets
2021Platelet mitochondria can be used in the study of mitochondrial dysfunction in various complex diseases and can help in finding biological markers for diagnosing the disease, monitoring its course and the effects of treatment. The aim of this chapter was to describe in detail the method of measuring mitochondrial respiration in platelets using high ...
Zdeněk, Fišar, Jana, Hroudová
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Effects of Cobalt on Mitochondrial Respiration
Nature, 1963Dingle, Heath, Webb, and Daniel have suggested that the toxicity of cobalt (II) is due to inhibition of keto-acid oxidation1. This hypothesis was supported by the finding that cobalt (II) inhibited oxidation of α-ketoglutarate and pyruvate by rat liver mitochondria during a prolonged incubation without the addition of phosphate acceptor1.
E H, STRICKLAND, C R, GOUCHER
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Ochratoxin A: Inhibition of Mitochondrial Respiration
Science, 1970Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low ...
J H, Moore, B, Truelove
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Mitochondrial regulation of tissue respiration
American Journal of Physiology-Legacy Content, 1959Mitochondrial and nuclear counts and homogenate and washed mitochondrial qO2 determinations were made on kidney cortex, liver and brain of albino rats. Homogenate qO2 was inversely related to mitochondrial count in the three tissues, but directly related to cellularity and to O2 uptake per mitochondrion.
A T, MILLER +3 more
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Regulation of Mitochondrial Respiration in Liver
1986In studies on the control of mitochondrial respiration carried out in the past 10 years, particular attention has been focussed on cytochrome c oxidase and the adenine nucleotide translocator as rate-controlling steps. On the basis of the observation that the first two phosphorylation sites of the respiratory chain are in near equilibrium with the ...
Verhoeven, A. J. +5 more
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The effect of camphor on mitochondrial respiration
Experientia, 1982Camphor at less than 8 mumoles/mg protein reduced the rate of oxygen consumption by rat liver mitochondria. The effect occurs only with NAD+-linked substrates. Succinate linked respiration was inhibited but this appears to be caused by some conversion of succinate to malate.
D F, Guilland-Cumming, G J, Smith
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p53 Regulates Mitochondrial Respiration
Science, 2006The energy that sustains cancer cells is derived preferentially from glycolysis. This metabolic change, the Warburg effect, was one of the first alterations in cancer cells recognized as conferring a survival advantage. Here, we show that p53, one of the most frequently mutated genes in cancers, modulates the balance between the ...
Satoaki, Matoba +8 more
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