Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
Streptococcal Pyrogenic Exotoxin B-Induced Apoptosis in A549 Cells Is Mediated by a Receptor- and Mitochondrion-Dependent Pathway [PDF]
, 2004 Wan-Hua Tsai +7 more
openalex +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 Mazat, Jean-Pierre +4 more
openaire +1 more source
Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions
Advanced Healthcare Materials, EarlyView.A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang +12 more
wiley +1 more source
Average volume of mitochondrion, nucleous, heterochromatin and euchromatin in hexamethylene bisacetamide (HMBA) induced human colonic carcinoma cell line (Lovo) [PDF]
, 1998 Tyh Lau, Annie L.M. Cheung, GL Tipoe
openalex
ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing
Advanced Healthcare Materials, EarlyView.A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha +4 more
wiley +1 more source
Phylogenetic analyses suggest lateral gene transfer from the mitochondrion to the apicoplast
, 2002 Miroslav Obornı́k +6 more
openalex +2 more sources
The mitochondrion – an organelle commonly involved in programmed cell death in Arabidopsis thaliana [PDF]
, 2004 Nan Yao +3 more
openalex +1 more source
Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source