Results 151 to 160 of about 344,643 (260)

Correction: Islam et al. Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology. <i>Nanomaterials</i> 2021, <i>11</i>, 2757. [PDF]

Nanomaterials (Basel)
Islam R, Sun L, Zhang L.
europepmc   +1 more source

The molecular biology of the mitochondrion [PDF]

Biochemical Journal, 1982
openaire   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Modular Design of Mitochondrion-Targeted Iron Chelators Allows Highly Selective Antiparasitic Activity against Trypanosomes and Apicomplexan Parasites. [PDF]

ACS Infect Dis
Malych R, Bordat Y, Klanicová K, Arbon D, Zahedifard F, Šipková A, Drncová E, Levytska V, Mach J, Plutowski-Wrobel L, Machado M, Štursa J, Truksa J, Ganter M, Sojka D, Zoltner M, Besteiro S, Werner L, Sutak R.   +18 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Cell-type-targeted mitochondrial transplantation rescues cell degeneration. [PDF]

Nature
Ayupov T, Moreno-Juan V, Curtoni S, Fratzl A, Sharma U, Posada-Céspedes S, Ratiu R, Morikawa R, Meyer AG, Pezzoli M, Bantug G, Chevalier M, Hou Y, Nadeau SA, Herrero-Navarro Á, Ayinampudi V, Kastanaki E, Whitehead N, Siwicki RA, Ribeiro MM, Han JH, Bucci A, Hess C, Picelli S, Renner M, Müller DJ, Cowan CS, Hansen S, Roska B.   +28 more
europepmc   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Single-Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers. [PDF]

Adv Sci (Weinh)
Xiao X, Lu C, Chen H, Zhou J, Hu Y, Di H, Su G, Yan X.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites. [PDF]

PLoS Pathog
Loveridge KM, Sigala PA.
europepmc   +1 more source