Results 171 to 180 of about 344,643 (260)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

First Direct Evidence for a Structurally Stable Adhesion Between the Perialgal Vacuole Membrane and Host Mitochondria in the <i>Paramecium</i>-<i>Chlorella</i> Endosymbiosis. [PDF]

Biomolecules
Fujishima M, Nishiyama S.
europepmc   +1 more source

A case of auris interna and transcortical lesion observed in the mitochondrion brain muscular disease.

, 1997
Satoshi Iwasaki
openalex   +2 more sources

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Quantitative reconstruction of neuronal mitochondrial network in neurites and somata in rat hippocampus and prefrontal cortex. [PDF]

Front Physiol
Wang L, Li L, Liu J, Wang Z, Liu J, Chang S, Yuan J, Chen X, Xie Q, Shen L, Wang X, Li G, Cheng H, Han H.   +13 more
europepmc   +1 more source

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

, 2013
Tomohisa Mori, Teruo Hayashi, Eri Hayashi, Tsung‐Ping Su   +3 more
openalex   +2 more sources

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Eukaryogenesis: Did an Oxidative Crucible Result in Misleading Bioinformatic Analyses? [PDF]

Bioessays
Speijer D.
europepmc   +1 more source

A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals

, 2015
Fang Si, Yang Liu, Kelu Yan, Wenwan Zhong   +3 more
openalex   +2 more sources

tRNA modification in the mitochondrion

Reactome - a curated knowledgebase of biological pathways, 2015
openaire   +1 more source