Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway [PDF]
, 2019 Hideaki Tanaka +7 more
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Advanced Healthcare Materials, EarlyView.Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae +9 more
wiley +1 more source
Pyruvate:NADP Oxidoreductase from the Mitochondrion of Euglena gracilis and from the Apicomplexan Cryptosporidium parvum: A Biochemical Relic Linking Pyruvate Metabolism in Mitochondriate and Amitochondriate Protists [PDF]
, 2001 Carmen Rotte +4 more
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Advanced Materials, EarlyView.A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen +7 more
wiley +1 more source
On the evolutionary origin of the plant mitochondrion and its genome
, 1989 Michael W. Gray +3 more
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Advanced Materials, EarlyView.This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle +9 more
wiley +1 more source
Advanced Materials, Volume 37, Issue 13, April 2, 2025.A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou +10 more
wiley +1 more source
A novel targeting domain directs essential components of the cytosolic iron-sulfur cluster assembly pathway to the mitochondrion of Toxoplasma parasites. [PDF]
PLoS BiolHodgson ER +4 more
europepmc +1 more source
An actin‐like protein (green) in Leishmania donovani promastigotes is mainly localized in the mitochondrion. Depletion of the intracellular levels of this protein leads to a decrease in mitochondrial function and also impairment of flagellum assembly and motility. Nucleus and kinetoplast (cyan) are also shown. For further details readers are referred to the article by Singh et al. on pp. 562–578 of this issue. [PDF]
, 2014 openalex +1 more source