Results 21 to 30 of about 328,766 (309)
A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes
eLife, 2020 Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx).
Samantha Ebersoll +4 more
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Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy
Neural Plasticity, 2020 Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial role in SNHL
Baoyi Feng +9 more
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Biochemistry and Molecular Biology Education, 2010 AbstractDiverse biological data may be used to create illustrations of molecules in their cellular context. I describe the scientific results that support a recent textbook illustration of a mitochondrion. The image magnifies a portion of the mitochondrion by one million times, showing the location and form of membranes and individual macromolecules ...
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Gazing at Translocation in the Mitochondrion [PDF]
Cell, 2008 Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondrion via molecular machines called translocons on the outer and inner mitochondrial membranes. Alder et al. (2008b) examine protein translocation into intact mitochondria by adapting fluorescent techniques first used to study translocation in the endoplasmic ...
Susan Walsh, Carla M. Koehler
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Lead and the mitochondrion [PDF]
Postgraduate Medical Journal, 1975 Summary In studies on the distribution of lead in rats given drinking water containing lead acetate at concentrations: 0, 100, 500, 1000 and 5000 μgPb/l for one year, no change was observed in the organ distribution of lead, or in the subcellular distribution of lead in the organelles in the heart. The mitochondrial enzyme,
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A patatin-like phospholipase is important for mitochondrial function in malaria parasites
mBio, 2023 Plasmodium parasites rely on a functional electron transport chain (ETC) within their mitochondrion for proliferation, and compounds targeting mitochondrial functions are validated antimalarials.
Emma Pietsch +12 more
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Frontiers in Veterinary Science, 2022 Endurance training and explosive strength training, with different contraction protein and energy metabolism adaptation in skeletal muscle, are both beneficial for physical function and quality of life.
Guli Xu +7 more
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Cells, 2021 Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska +9 more
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Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis
Life, 2021 Mitochondrial dysfunction is associated with a wide range of chronic human disorders, including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that undergo constant turnover in living cells.
Alexander M. Markin +7 more
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Cell Reports, 2017 Summary: A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and human
Jacqueline Morris +16 more
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