Results 21 to 30 of about 338,550 (257)

Cytoprotective Effects of Punicalagin on Hydrogen–Peroxide–Mediated Oxidative Stress and Mitochondrial Dysfunction in Retinal Pigment Epithelium Cells

Antioxidants, 2021
The retinal pigment epithelium (RPE) is a densely pigmented, monostratified epithelium that provides metabolic and functional support to the outer segments of photoreceptors. Endogenous or exogenous oxidative stimuli determine a switch from physiological
Maria Elisabetta Clementi, Giuseppe Maulucci, Giada Bianchetti, Michela Pizzoferrato, Beatrice Sampaolese, Giuseppe Tringali   +5 more
doaj   +1 more source

Design and Synthesis of a Mitochondria-Targeting Radioprotectant for Promoting Skin Wound Healing Combined with Ionizing Radiation Injury

Pharmaceuticals, 2022
Wound healing is seriously retarded when combined with ionizing radiation injury, because radiation-induced excessive reactive oxygen species (ROS) profoundly affect cell growth and wound healing. Mitochondria play vital roles not only as cellular energy
Zaizhi Du, Han Liu, Xie Huang, Yang Li, Liting Wang, Jing Liu, Shuang Long, Rong Li, Qiang Xiang, Shenglin Luo   +9 more
doaj   +1 more source

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Cells, 2021
Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Artur Jóźwik, Anna Walaszczyk, Karol Jelonek, Grażyna Szczukiewicz-Markowska, Olaf K. Horbańczuk, Monika Pietrowska, Piotr Widłak, Dorota Gabryś   +9 more
doaj   +1 more source

Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis

Life, 2021
Mitochondrial dysfunction is associated with a wide range of chronic human disorders, including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that undergo constant turnover in living cells.
Alexander M. Markin, Viktoria A. Khotina, Xenia G. Zabudskaya, Anastasia I. Bogatyreva, Antonina V. Starodubova, Ekaterina Ivanova, Nikita G. Nikiforov, Alexander N. Orekhov   +7 more
doaj   +1 more source

Is Myelin a Mitochondrion? [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2012
It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin ...
Harris, Julia J, Attwell, David
openaire   +2 more sources

High-Throughput Genomic Data Reveal Complex Phylogenetic Relationships in Stylosanthes Sw (Leguminosae)

Frontiers in Genetics, 2021
Allopolyploidy is widely present across plant lineages. Though estimating the correct phylogenetic relationships and origin of allopolyploids may sometimes become a hard task. In the genus Stylosanthes Sw.
Maria Alice Silva Oliveira, Tomáz Nunes, Maria Aparecida Dos Santos, Danyelle Ferreira Gomes, Iara Costa, Brena Van-Lume, Sarah S. Marques Da Silva, Ronaldo Simão Oliveira, Marcelo F. Simon, Gaus S. A. Lima, Danilo Soares Gissi, Cícero Carlos de Souza Almeida, Gustavo Souza, André Marques, André Marques   +14 more
doaj   +1 more source

A patatin-like phospholipase is important for mitochondrial function in malaria parasites

mBio, 2023
Plasmodium parasites rely on a functional electron transport chain (ETC) within their mitochondrion for proliferation, and compounds targeting mitochondrial functions are validated antimalarials.
Emma Pietsch, Abhinay Ramaprasad, Sabrina Bielfeld, Yvonne Wohlfarter, Bohumil Maco, Korbinian Niedermüller, Louisa Wilcke, Joachim Kloehn, Markus A. Keller, Dominique Soldati-Favre, Michael J. Blackman, Tim-Wolf Gilberger, Paul-Christian Burda   +12 more
doaj   +1 more source

Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1

Frontiers in Veterinary Science, 2022
Endurance training and explosive strength training, with different contraction protein and energy metabolism adaptation in skeletal muscle, are both beneficial for physical function and quality of life.
Guli Xu, Yexian Yuan, Pei Luo, Jinping Yang, Jingjing Zhou, Canjun Zhu, Qingyan Jiang, Gang Shu   +7 more
doaj   +1 more source

Visualization of a Mammalian Mitochondrion by Coherent X-ray Diffractive Imaging

Scientific Reports, 2017
We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation.
Yoonhee Kim, Chan Kim, Ou Young Kwon, Daewoong Nam, Sang Soo Kim, Jae Hyun Park, Sunam Kim, Marcus Gallagher-Jones, Yoshiki Kohmura, Tetsuya Ishikawa, Changyong Song, Giyoong Tae, Do Young Noh   +12 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source