Results 61 to 70 of about 226,740 (385)

Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae

Pathogens, 2020
Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences
Evgeny S. Gerasimov, Ksenia A. Zamyatnina, Nadezda S. Matveeva, Yulia A. Rudenskaya, Natalya Kraeva, Alexander A. Kolesnikov, Vyacheslav Yurchenko   +6 more
doaj   +1 more source

Role of Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology

Frontiers in Cell and Developmental Biology, 2022
Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from generating energy, regulating the metabolic processes, cell death to inflammation.
Arpita Chowdhury, Steffen Witte, Abhishek Aich, Abhishek Aich   +3 more
doaj   +1 more source

Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]

, 2018
Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo, Hejchman, Elżbieta, Hernández Rodríguez, Vanessa, Pinto Martinez, Andrea, Rodríguez Durán, Jessica Jenireth   +4 more
core   +1 more source

The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion

International Journal of Molecular Sciences, 2020
Currently, it is known that, in living systems, free radicals and other reactive oxygen and nitrogen species play a double role, because they can cause oxidative damage and tissue dysfunction and serve as molecular signals activating stress responses ...
P. Venditti, S. Di Meo
semanticscholar   +1 more source

A nonmitochondrial hydrogen production in Naegleria gruberi [PDF]

, 2014
Naegleria gruberi is a free-living heterotrophic aerobic amoeba well known for its ability to transform from an amoeba to a flagellate form. The genome of N.
Anastasios D. Tsaousis, Bui, Cable, Ellis, Embley, Embley, Embley, Eva Nývltová, Fritz-Laylin, Fritz-Laylin, Fromm, Fulton, Helianti, Hug, Ivan Hrdý, Jan Tachezy, Kamp, Koonin, Lithgow, Lloyd, Majewski, Martin, Mentel, Meyer, Muller, Netz, Nicolet, Niedenthal, Nixon, Nyvltova, Opperdoes, Peters, Putz, Rasoloson, Robert Šuták, Sambrook, Stechmann, Sutak, Tsaousis, Vignais   +39 more
core   +2 more sources

Dietary Supplementation With High Fiber Alleviates Oxidative Stress and Inflammatory Responses Caused by Severe Sepsis in Mice Without Altering Microbiome Diversity

Frontiers in Physiology, 2019
In this study, we demonstrated the effects of a high-fiber diet on intestinal lesions, oxidative stress and systemic inflammation in a murine model of endotoxemia.
Yuanyuan Zhang, Aili Dong, Keliang Xie, Yonghao Yu   +3 more
doaj   +1 more source

Sabotage at the Powerhouse? Unraveling the Molecular Target of 2-Isopropylbenzaldehyde Thiosemicarbazone, a Specific Inhibitor of Aflatoxin Biosynthesis and Sclerotia Development in Aspergillus flavus, Using Yeast as a Model System

Molecules, 2019
Amongst the various approaches to contain aflatoxin contamination of feed and food commodities, the use of inhibitors of fungal growth and/or toxin biosynthesis is showing great promise for the implementation or the replacement of conventional pesticide ...
Cristina Dallabona, Marianna Pioli, Giorgio Spadola, Nicolò Orsoni, Franco Bisceglie, Tiziana Lodi, Giorgio Pelosi, Francesco Maria Restivo, Francesca Degola   +8 more
doaj   +1 more source

Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

eLife, 2015
IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function.
Rui Yang, Dario Lirussi, Tina M Thornton, Dawn M Jelley-Gibbs, Sean A Diehl, Laure K Case, Muniswamy Madesh, Douglas J Taatjes, Cory Teuscher, Laura Haynes, Mercedes Rincón   +10 more
doaj   +1 more source

Cryo-electron tomography reveals novel features of a viral RNA replication compartment

eLife, 2017
Positive-strand RNA viruses, the largest genetic class of viruses, include numerous important pathogens such as Zika virus. These viruses replicate their RNA genomes in novel, membrane-bounded mini-organelles, but the organization of viral proteins and ...
Kenneth J Ertel, Desirée Benefield, Daniel Castaño-Diez, Janice G Pennington, Mark Horswill, Johan A den Boon, Marisa S Otegui, Paul Ahlquist   +7 more
doaj   +1 more source

The complete mitochondrial genome of Pareuchiloglanis feae (Siluriformes, Sisoridae, Pareuchiloglanis): genome characterization and phylogenetic analysis

Mitochondrial DNA. Part B. Resources, 2022
Pareuchiloglanis feae is mainly distributed in Irrawaddy (China and Myanmar), Salween (China and Myanmar), and the Yangtze River drainage areas. In this study, the complete mitochondrial genome of P.
Sheng Zeng, Xue Wang, Wei Liu, Yan Xiang, Lu Zhou   +4 more
doaj   +1 more source