Results 71 to 80 of about 15,616 (228)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, Volume 20, Issue 2, Page 428-446, February 2026.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Análisis de la función y ultraestructura mitocondrial en ratones albinos sanos tratados con medicamentos para insuficiencia cardíaca.

Revista de la Facultad de Ciencias Médicas de Córdoba, 2017
 ResumenIntroducción: la actividad mitocondrial es esencial para el músculo cardíaco y esquelético. La relación entre la disfunción mitocondrial y diferentes condiciones cardiovasculares ha sido bien descrita.
Gaston Oscar Camino Willhuber, Gustavo Guzman Mentesana, Alejandra Baez, Silvina Lo Presti, Carolina Bazán, Mariana Strauss, Ricardo Fretes, Patricia Adriana Paglini-Oliva, Hector Walter Rivarola   +8 more
doaj   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Fármacos de uso oftálmico, situación actual y nuevos fármacos en desarrollo [PDF]

, 2018
En la actualidad la prescripción de medicamentos para uso oftálmico es de gran importancia, debido alas características únicas del medio ocular.
Serrano Giménez, Pablo
core  

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, Volume 293, Issue 4, Page 1089-1105, February 2026.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Estudos citológicos e citoquímicos em Stenophoridae Crawley, 1903 (Eugregarinidae, Protozoa) II - ultra-estrutura

Memorias do Instituto Oswaldo Cruz, 1967
1 - Indivíduos de Stenophora juli (Frantzius, 1848) Labbé, 1899, parasitos de um Diplopoda, Rhinochricus padbergi Schubart. 1930 foram examinados em microscópia óptica e eletrônica.
Sylvio Celso Goncalves da Costa, Ortrud Monika Barth   +1 more
doaj   +1 more source

Dictyostelium discoideum, una ameba peculiar [PDF]

, 2011
Dictyostelium discoideum és una ameba unicel·lular, encara que també presenta una etapa de desenvolupament multicel·lular en el seu cicle biològic. Aquest organisme ha estat utilitzat com un sistema model des de fa més de quaranta anys a causa de la seva
Galardi-Castilla, María, Sastre, Leandro   +1 more
core  

Label‐free imaging of intracellular structures in living mammalian cells via external apodization phase‐contrast microscopy

The FEBS Journal, Volume 293, Issue 4, Page 1127-1149, February 2026.
Advanced techniques to visualize the spatiotemporal functionality of biomolecules are essential for elucidating mechanisms governing cellular behavior. External apodization phase‐contrast (ExAPC) microscopy enables label‐free visualization of diverse intracellular structures in living mammalian cells. By enhancing phase‐contrast imaging through optical
Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Teppei Nishino, Yusuke Hayashi, Yusuke Yamamoto, Shin‐Ichiro Takahashi, Yuta Mishima, Yosuke Yoneyama, Yoshinori Takeuchi, Motohiro Sekiya, Takashi Matsuzaka, Takafumi Miyamoto, Hitoshi Shimano   +19 more
wiley   +1 more source

Avaliação do intumescimento osmótico mitocondrial do fígado submetido a isquemia parcial e ao pré-condicionamento isquêmico

Acta Cirúrgica Brasileira, 2000
O objetivo deste trabalho foi avaliar a permeabilidade da membrana mitocondrial em animais submetidos a pré-condicionamento isquêmico, isquemia e reperfusão seguido de hepatectomia a 70%.
A.B. Barbosa Jr, Maria Cecilia Jordani, Maria Eliza J. de Souza, Clarice F.F. Franco, Maria Ap. N.C. Picinato, Orlando Castro e Silva Jr.   +5 more
doaj   +1 more source

Dexmedetomidine Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury in Rats by Suppressing Mitophagy Via Activating Α2-Adrenergic Receptor. [PDF]

Arq Bras Cardiol, 2023
Chen Y, Chen H, Chen Y, Yang Z, Zhou T, Xu W.   +5 more
europepmc   +1 more source