Results 91 to 100 of about 520,457 (360)

Mitogen-Activated Protein Kinase Activation Through Fcε Receptor I and Stem Cell Factor Receptor Is Differentially Regulated by Phosphatidylinositol 3-Kinase and Calcineurin in Mouse Bone Marrow-Derived Mast Cells [PDF]

, 1999
Tamotsu Ishizuka, Kazuaki Chayama, Katsuyuki Takeda, Eckard Hamelmann, Naohiro Terada, Gordon Keller, Gary L. Johnson, Erwin W. Gelfand   +7 more
openalex   +1 more source

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades*

Journal of Biological Chemistry, 1998
Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral membrane proteins involved in the transmission of signals from the extracellular environment to the cytoplasm. The best known family of G protein-coupled receptors (GPCRs),
J. Gutkind
semanticscholar   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor*

Journal of Biological Chemistry, 1998
Interleukin-6 (IL-6) is a pleiotropic cytokine, which is involved in inflammatory and immune responses, acute phase reactions, and hematopoiesis. In the mouse fibrosarcoma cell line L929, the nuclear factor (NF)-κB plays a crucial role in IL-6 gene ...
W. Vanden Berghe, S. Plaisance, E. Boone, K. De Bosscher, M. Schmitz, W. Fiers, G. Haegeman   +6 more
semanticscholar   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target

Therapeutic Advances in Medical Oncology, 2019
One of the mitogen-activated protein kinases (MAPKs), c-Jun NH2-terminal protein kinase (JNK) plays an important role in regulating cell fate, such as proliferation, differentiation, development, transformation, and apoptosis.
Jae Gwang Park, Nur Aziz, Jae Youl Cho
doaj   +1 more source

Inhibitory effect of p38 mitogen‐activated protein kinase inhibitors on cytokine release from human macrophages [PDF]

, 2006
Susan J. Smith, P.S. Fenwick, Andrew G. Nicholson, Ford Kirschenbaum, Tricia Finney‐Hayward, Linda S. Higgins, M A Giembycz, Peter J. Barnes, Louise Donnelly   +8 more
openalex   +1 more source

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Putative mechanism of a multivitamin treatment against insulin resistance

Adipocyte
Insulin resistance is caused by the abnormal secretion of proinflammatory cytokines in adipose tissue, which is induced by an increase in lipid accumulation in adipocytes, hepatocytes, and myocytes. The inflammatory pathway involves multiple targets such
José Antonio Palma-Jacinto, Edgar López-López, José Luis Medina-Franco, Oreth Montero-Ruíz, Isela Santiago-Roque   +4 more
doaj   +1 more source

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

Frontiers in Plant Science, 2015
In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28 and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induces genes.
G.H.M. eSagor, Pratima eChawla, Dong Wook eKim, Thomas eBerberich, Seiji eKojima, Masaru eNiitsu, Tomonobu eKusano   +6 more
doaj   +1 more source