Results 41 to 50 of about 458,508 (146)

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation [PDF]

, 2019
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited
Agostinelli, Enzo, Antonucci, Laura, Bordone, Rosa, Caimano, Miriam, Canettieri, Gianluca, Capalbo, Carlo, Checquolo, Saula, Coni, Sonia, D'Amico, Davide, De Smaele, Enrico, Di Magno, Laura, Di Marcotullio, Lucia, Di Pastena, Fiorella, Giorgi, Alessandra, Manni, Simona, Maroder, Marella, Petroni, Marialaura, Schininà, Maria Eugenia, Serrao, Silvia Maria, Yates Iii, John R, Yurtsever, Zuleyha Nihan   +20 more
core   +1 more source

Activation of Mitogen-activated Protein Kinase by HO

Journal of Biological Chemistry, 1996
The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals.
K. Guyton, Yusen Liu, M. Gorospe, Qingbo Xu, N. Holbrook   +4 more
semanticscholar   +1 more source

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation [PDF]

, 2009
Transcription of the mast cell growth factor SCF (stem cell factor) is upregulated in inflammatory conditions, and this is dependent upon NF-kappaB, as well as the MAP kinases p38 and ERK activation.
Frossard, Nelly, Haegeman, Guy, Reber, Laurent, Vermeulen, Linda   +3 more
core   +3 more sources

When kinases meet mathematics: the systems biology of MAPK signalling [PDF]

, 2005
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified ...
Becskei, Becskei, Bhalla, Black, Boldt, Brightman, Butcher, Chapman, Cho, Corbit, David Gilbert, Dhillon, Dhillon, Douville, Eblen, Ferrell, Ferrell, Goldbeter, Gong, Hatakeyama, Hayashi, Hoang, Kholodenko, Kofahl, Kolch, Langlois, Levchenko, Morrison, Muffy Calder, Muller, Murphy, Resat, Rinehart, Sauro, Schoeberl, Somsen, Teis, Vaudry, Vayttaden, Walter Kolch, Wellbrock, Whitehurst, Wiley, Xiong, Yeung   +44 more
core   +1 more source

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]

, 2018
Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa, Boknik, Peter, Dos Remedios, Cris G, Gergs, Ulrich, Hamdani, Nazha, Krysiak, Judith, Linke, Wolfgang A, Redfield, Margaret M, Sheikh, Farah, Unger, Andreas, von Frieling-Salewsky, Marion   +10 more
core   +3 more sources

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*

Journal of Biological Chemistry, 2001
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously, it has been shown that Akt can activate the transcription factor NF-κB and that this functions to block apoptosis induced ...
L. Madrid, M. Mayo, J. Reuther, A. Baldwin   +3 more
semanticscholar   +1 more source

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

Phosphoregulators:protein kinases and protein phosphatases of mouse [PDF]

, 2003
With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational approach to identify and classify all of the protein ...
, , Forrest, Alistair R.R., Grimmond, Sean, Huber, Thomas, Hume, David A., Ravasi, Timothy, Taylor, Darrin   +7 more
core   +2 more sources

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]

, 2006
BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore, Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Jones, Toni L, Rosengren, Sanna, Sorkin, Linda, Svensson, Camille I   +7 more
core   +3 more sources