Results 181 to 190 of about 229,005 (218)

MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus

Lupus, 2012
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles. The production of these cytokines is responsible for the mitogen-activated protein kinases (MAPKs), which can ...
J, Yang, Y-W, Lu, M-M, Lu, R-X, Leng, H-F, Pan, D-Q, Ye   +5 more
openaire   +2 more sources

Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation

Acta Crystallographica Section F Structural Biology Communications, 2021
Eukaryotic protein kinases contain an Asp-Phe-Gly (DFG) motif, the conformation of which is involved in controlling the catalytic activity, at the N-terminus of the activation segment. The motif can be switched between active-state (DFG-in) and inactive-state (DFG-out) conformations: however, the mechanism of conformational change is poorly understood,
Setsu Nakae, Maho Kitamura, Daisuke Fujiwara, Masaaki Sawa, Tsuyoshi Shirai, Ikuo Fujii, Toshiji Tada   +6 more
openaire   +2 more sources

Mitogen-activated protein kinase phosphatase-1 in olfactory neural regeneration

NeuroReport, 2000
Uniquely, olfactory neurons continuously replace themselves. Olfactory bulb ablation induces coordinated degeneration and regeneration in olfactory neuroepithelium; up-regulated growth factors bind to their receptors, initiating a phosphorylation cascade activating mitogen-activated protein kinases (MAPK).
M, Shinogami, T, Ishibashi
openaire   +2 more sources

Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium

Journal of Cardiac Failure, 2002
Mitogen-activated protein kinases (MAPKs), consisting of the ERK1/2, JNKs, and p38-kinase families, play a key role in the regulation of myocyte growth and apoptosis in vitro. The activity of MAPKs is regulated by dual-specificity MAPK phosphatases (MKPs). Because myocardial failure is associated with myocyte hypertrophy and apoptosis, MAPKs may play a
Catherine, Communal, Wilson S, Colucci, Andrea, Remondino, Douglas B, Sawyer, J David, Port, Scott E, Wichman, Michael R, Bristow, Krishna, Singh   +7 more
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Regulation of tristetraprolin expression by mitogen‐activated protein kinase phosphatase‐1

APMIS, 2012
Tristetraprolin (TTP) is an acute phase protein, and its expression is rapidly up‐regulated by inflammatory signals, such as lipopolysaccharide (LPS) and cytokines. TTP regulates gene expression by governing the mRNA stability of its target genes, which include cytokines and growth factors. MAP kinase phosphatase‐1 (MKP‐1) is a nuclear phosphatase that
Noora, Huotari, Tuija, Hömmö, Ville, Taimi, Riina, Nieminen, Eeva, Moilanen, Riku, Korhonen   +5 more
openaire   +2 more sources

Hypoxia and Hypoxia/Reoxygenation Activate Raf-1, Mitogen-Activated Protein Kinase Kinase, Mitogen-Activated Protein Kinases, and S6 Kinase in Cultured Rat Cardiac Myocytes

Circulation Research, 1996
Abstract In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia or hypoxia followed by reoxygenation (hypoxia ...
Y, Seko, K, Tobe, K, Ueki, T, Kadowaki, Y, Yazaki   +4 more
openaire   +2 more sources

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

Science, 1993
The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known about the protein interactions that bring about its biological activity. Wild-type Ras or mutant forms of Ras were covalently attached to an insoluble matrix and then used to examine the interaction of signaling proteins ...
Moodie, S.A., Willumsen, Berthe Marie, Weber, M. J., Wolfman, A.   +3 more
openaire   +2 more sources

Interdependent Domains Controlling the Enzymatic Activity of Mitogen-Activated Protein Kinase Kinase 1

Biochemistry, 1996
The activation of human mitogen-activated protein kinase kinase 1 (MKK1) is achieved by phosphorylation at Ser218 and Ser222 within a regulatory loop. Partial activation was achieved by replacing these residues with aspartic/glutamic acid. Higher activity was obtained by introducing four acidic residue substitutions in the regulatory loop, indicating ...
S J, Mansour, J M, Candia, J E, Matsuura, M C, Manning, N G, Ahn   +4 more
openaire   +2 more sources

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1

Bioorganic & Medicinal Chemistry, 2006
Protein tyrosine phosphatases have a central role in the maintenance of normal cellular functionality. For example, PTP1B has been implicated in insulin-resistance, obesity, and neoplasia. Mitogen-activated protein kinase phosphatase-1 (MKP-1 or DUSP1) dephosphorylates and inactivates mitogen-activated protein kinase (MAPK) substrates, such as p38, JNK,
John S, Lazo, Ruth, Nunes, John J, Skoko, Pierre E, Queiroz de Oliveira, Andreas, Vogt, Peter, Wipf   +5 more
openaire   +2 more sources

Induction of Mitogen-Activated Protein Kinase Phosphatase-1 During Acute Hypertension

Hypertension, 1997
Abstract Recently, we demonstrated that elevated blood pressure activates mitogen-activated protein (MAP) kinases in rat aorta. Here we provide evidence that the vascular response to acute hypertension also includes induction of MAP kinase phosphatase-1 (MKP-1), which has been shown to function in the dephosphorylation and ...
Q, Xu, T W, Fawcett, M, Gorospe, K Z, Guyton, Y, Liu, N J, Holbrook   +5 more
openaire   +2 more sources