Results 191 to 200 of about 229,005 (218)
Some of the next articles are maybe not open access.
Angiopoietin‐1 activates both anti‐ and proapoptotic mitogen‐activated protein kinases
The FASEB Journal, 2003ABSTRACT In this study, we identified whether mitogen‐activated protein kinases (MAPKs) mediate the effects of angiopoietin‐1 (Ang‐1) on endothelial cell apoptosis. Exposure of human umbilical vein endothelial cells to Ang‐1 (300 ng/ml) evoked within 15–30 min a 15‐fold and a 5‐fold increase in phosphorylation of ERK1/2 and p38 MAPKs,
Rania, Harfouche +5 more
openaire +2 more sources
Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader
Journal of Medicinal Chemistry, 2019MEK1 and MEK2 (also known as MAP2K1 and MAP2K2) are the "gatekeepers" of the ERK signaling output with redundant roles in controlling ERK activity. Numerous inhibitors targeting MEK1/2 have been developed including three FDA-approved drugs. However, acquired resistance to MEK1/2 inhibitors has been observed in patients, and new therapeutic strategies ...
Jieli Wei +7 more
openaire +2 more sources
UniProt: the universal protein knowledgebase in 2021
Nucleic Acids Research, 2021Alex Bateman +2 more
exaly
Accurate prediction of protein structures and interactions using a three-track neural network
Science, 2021Minkyung Baek +2 more
exaly