Results 61 to 70 of about 229,005 (218)
Mechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytes
Scientific Reports, 2023 Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue.
Magdaléna Vaváková +3 more
doaj +1 more source
Mnk1 (Mitogen-Activated Protein Kinase–Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice [PDF]
Hypertension, 2016 Identifying the key factor involved in cardiac remodeling is critically important for developing novel strategies to protect against heart failure. Here, the role of Mnk1 (mitogen-activated protein kinase–interacting kinase 1) in cardiac remodeling was clarified. Cardiac remodeling was induced by transverse aortic constriction in Mnk1-knockout mice and
Yuan, Yuan +12 more
openaire +2 more sources
Mitogen-Activated Protein Kinases and Mitogen Kinase Phosphatase 1: A Critical Interplay in Macrophage Biology [PDF]
Frontiers in Molecular Biosciences, 2016 Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages.
Lloberas Cavero, Jorge +4 more
openaire +3 more sources
Frontiers in Microbiology, 2019 The impact of gut microbiota and its metabolites on fat metabolism have been widely reported in human and animals. However, the critical mediators and the signal transductions are not well demonstrated.
Jian-Mei Zhang +11 more
doaj +1 more source
Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions [PDF]
Cellular and Molecular Life Sciences, 2012 The balance of protein phosphorylation is achieved through the actions of a family of protein serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases (MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation.
Ahmed, Lawan +3 more
openaire +2 more sources
Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function [PDF]
, 2023 Rania Saeed +5 more
openalex +1 more source
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease [PDF]
Life Sciences, 2012 Mitogen-activated protein kinases (MAPKs) are key regulators of cellular physiology and immune responses, and abnormalities in MAPKs are implicated in many diseases. MAPKs are activated by MAPK kinases through phosphorylation of the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr domain, where Xaa represents amino acid residues ...
Lyn M, Wancket +2 more
openaire +2 more sources
eLife, 2019 Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals.
Adelaida M Celaya +7 more
doaj +1 more source
Advances in Pharmacological and Pharmaceutical SciencesThe primary reason for cancer-related fatalities is metastasis. The compound 4-carbomethoxyl-10-epigyrosanoldie E, derived from the Sinularia sandensis soft coral species grown in cultures, exhibits properties that counteract inflammation.
Rou-Yi Fang +6 more
doaj +1 more source
Journal of Ginseng Research, 2019 Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic ...
Jung-Hae Shin +3 more
doaj +1 more source