Results 171 to 180 of about 227,000 (310)

Mitogen-Activated Protein Kinase and Protein Kinase A Signaling Pathways Stimulate Cholecystokinin Transcription via Activation of Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein [PDF]

, 1999
Thomas van Overeem Hansen, Jens F. Rehfeld, Finn Cilius Nielsen   +2 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Intermittent pH changes suggest acceleration of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/ protein kinase B (AKT) pathways.

Ryota Nishida (22258400), Tomoaki Fukui (4777479), Kenichi Sawauchi (22258403), Yohei Kumabe (4777482), Hyuma Kondo (22258406), Yuya Yamamoto (667024), Kyohei Takase (22258409), Ryo Yoshikawa (5075996), Takahiro Niikura (344625), Ryosuke Kuroda (735024), Keisuke Oe (344623)   +10 more
openalex   +1 more source

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells [PDF]

, 2010
Jong‐Eun Kim, Joe Eun Son, Sung Keun Jung, Nam Joo Kang, Chang Yong Lee, Ki Won Lee, Hyong Joo Lee   +6 more
openalex   +1 more source

Roles of phosphatidylinositol 3‐kinase and p38 mitogen‐activated protein kinase in the regulation of protein kinase C‐α activation in interferon‐γ‐stimulated macrophages [PDF]

, 2009
Pierre‐Olivier Hardy, Tamsir O. Diallo, Christine Matte, Albert Descoteaux   +3 more
openalex   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5. [PDF]

Front Immunol
Yang B, Fang G, Marx I, Liu G, Skouras S, Sharma K, Walther DM, Bollinger Martinez S, Hubeau C, Shi Y, De Savi C, Huang X, Huhn A, Sawant R, Proctor WR, Dixit VS, Dong H, Weiss MM, Mainolfi N, Slavin A, Long AJ, Williams JA, Byrne FR.   +22 more
europepmc   +1 more source

Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

, 1999
Ann-Marie Conway, Soma Rakhit, Susan Pyne, Nigel J. Pyne   +3 more
openalex   +2 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Strategic risk assessment in oncology: Utilizing single-agent activity to boost combination therapy approvals. [PDF]

Contemp Clin Trials Commun
Kasim A, Anastasiou M, Loizou E, Dimakakos A, Georganaki M, Mourelatos I, Karelis P, Esposito M, Zhou H, Chen TT, Skaltsas D, Stockman P.   +11 more
europepmc   +1 more source