Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff +2 more
wiley +1 more source
Integrated proteomic and phosphoproteomic analysis reveals the MAPK cascade as a key regulator of ethylene-induced latex production in Hevea brasiliensis. [PDF]
Yang L +10 more
europepmc +1 more source
Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines [PDF]
Michael P. Scheid, Vincent Duronio
openalex +1 more source
Ganoderic acids confer neuroprotection in ischemic stroke by directly targeting MD2, thereby blocking MD2/TLR4 complex formation and downstream MAPK and NF‐κB activation. This suppresses microglia‐driven neuroinflammation and mitigates cerebral ischemic injury.
Ang Ma +17 more
wiley +1 more source
Inhibition of Phosphatidylinositol 3-Kinase or Mitogen-Activated Protein Kinase Kinase Leads to Suppression of p34cdc2 Kinase Activity and Meiotic Progression Beyond the Meiosis I Stage in Porcine Oocytes Surrounded with Cumulus Cells [PDF]
Masayuki Shimada +2 more
openalex +1 more source
EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren +15 more
wiley +1 more source
Dormancy Versus Germination: 3D Protein Modeling and Evolutionary Analyses Define the Roles of Genetic Variants in the Barley MKK3 Enzyme. [PDF]
Hrmova M +5 more
europepmc +1 more source
Loss of Interleukin 6 Results in Delayed Mammary Gland Involution: A Possible Role for Mitogen-Activated Protein Kinase and Not Signal Transducer and Activator of Transcription 3 [PDF]
Ling Zhao +2 more
openalex +1 more source
Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao +11 more
wiley +1 more source

