Results 121 to 130 of about 234,943 (363)

A Radioactive in vitro ERK3 Kinase Assay

Bio-Protocol, 2019
Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases that have an important role in signal transduction. Extracellular signal-regulated kinase 3 (ERK3), also known as MAPK6, is an atypical MAPK.
Lobna Elkhadragy, Weiwen Long
doaj   +1 more source

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg, Adams, Alexander, Bardwell, Barsyte-Lovejoy, Bhattacharyya, Bhattacharyya, Buschbeck, Caffrey, Cavanaugh, Chang, Chen, Coulombe, Drew, Emsley, Garai, Guo, Gupta, Gógl, Hayashi, Hu, Jacobs, Kabsch, Kato, Kato, Kondoh, Li, Liu, Liu, Liu, Ma, McCoy, Milanesi, Moscat, Murakami, Nakamura, Nakamura, Nakamura, Nishimoto, Pearson, Piserchio, Potthoff, Raman, Ranganathan, Regan, Reményi, Sharrocks, Sohn, Tanoue, Wang, Watson, Winn, Won, Zarrinpar, Zeke, Zhang, Zhou, Zhou   +57 more
core   +1 more source

Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase.

Journal of Biological Chemistry, 1992
Previously it has been shown that acute 12-O-tetradecanoylphorbol-13-acetate treatment of intact U937 cells results in activation of mitogen-activated protein (MAP) kinase and a MAP kinase activator. MAP kinase activator induces phosphorylation of MAP kinase on tyrosine and threonine residues, thereby activating MAP kinase.
Peter D. Adams, Peter J. Parker
openaire   +3 more sources

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage

Journal of Pharmacological Sciences, 2011
.: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao, Yoji Kyotani, Satoyasu Itoh, Hitoshi Nakayama, Minoru Isosaki, Masanori Yoshizumi   +5 more
doaj  

Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies [PDF]

arXiv, 2020
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the ...
arxiv  

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
A Ali, A Mitchell, A Plaine, A Roetzer, A Roetzer, A Walther, A Winkler, AA Duina, AE Piispanen, Alex Andrianopoulos, Alistair J. P. Brown, AP Gasch, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, BK Jakobsen, C Csank, C Giardina, C Queitsch, C San Jose, CA Munro, Carol Munro, CH de Dios, CJ Nobile, D Chen, DA Davis, DA Smith, DF Jarosz, DF Jarosz, DF Smith, DM Arana, DR Wysong, E Kussell, E Leberer, E Nikolaou, E Roman, EA Craig, EA Elion, ET Burt, F Estruch, F Lamoth, F Navarro-Garcia, F Navarro-Garcia, F Navarro-García, F Sherman, FA Guhad, G Degols, G Wiederrecht, G Wiederrecht, GJ Gallo, H Garreau, H Lavoie, HC Causton, I Tirosh, IV Ene, J Chen, J Zou, JL Brewster, JR Blankenship, K-H Chen, LA Walker, LA Walker, LE Cowen, Leah E. Cowen, Louise Walker, M Ramsdale, M Taipale, MD Leach, MD Leach, MD Leach, MD Leach, ME Feder, Michelle D. Leach, MM Bradford, N Shulga, P Gónzalez-Párraga, P Hawle, PD Cantero, PK Sorger, PK Sorger, R Alonso-Monge, R Alonso-Monge, R Diez-Orejas, RA Monge, RB Wilson, RS Hegde, RS Shapiro, S Bates, S Diezmann, S Kuge, S Nicholls, S Nicholls, S Nicholls, SD Singh, SH Millson, SK Prill, SL LaFayette, SL Rutherford, SM Noble, SM O'Rourke, SM Roe, Susan Budge, TT Wimalasena, VM Bruno, VM Bruno, WA Fonzi, WM Toone, X Zhang, Y Guo, Y Kamada   +110 more
core   +3 more sources

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj  

Involvement of the mitogen-activated protein (MAP) kinase signalling pathway in host cell invasion by Toxoplasma gondii

Parasite, 2000
Little is known about signalling in Toxoplasma gondii, but it is likely that protein kinases might play a key role in the parasite proliferation, differentiation and probably invasion.
Robert-Gangneux F., Creuzet C., Dupouy-Camet J., Roisin M.-P.   +3 more
doaj   +1 more source