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Mitogen-Activated Protein Kinase Kinase 4 (MKK4)

The International Journal of Biochemistry & Cell Biology, 2000
The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines. JNK is a member of the MAP kinase family and a key component of a stress activated protein kinase signalling pathway ...
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Mitogen-Activated Protein Kinase Signaling

2004
The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and ...
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Mitogen‐activated protein kinases and asthma

Journal of Cellular Physiology, 2004
AbstractMitogen‐activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical ...
PELAIA G.   +10 more
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Mitogen-Activated Protein Kinase Assays

2007
Polymorphonuclear neutrophils (PMN) play an essential role in host defense against bacteria and fungi through coordinated responses such as adhesion, migration, phagocytosis, secretion, and activation of the NADPH oxidase. The mitogen-activated protein kinases (MAPKs) and their activation kinase cascades, which transduce signals from the plasma ...
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Mitogen-activated protein kinase (MAPK)

Critical Care Medicine, 2005
Joseph, Cuschieri, Ronald V, Maier
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Mitogen‐activated protein kinase cascades in plant signaling

Journal of Integrative Plant Biology, 2022
Mengmeng Zhang, Shuqun Zhang
exaly  

AMP-activated protein kinase: the current landscape for drug development

Nature Reviews Drug Discovery, 2019
Gregory R Steinberg, David Carling
exaly  

Targeting proteinase-activated receptors: therapeutic potential and challenges

Nature Reviews Drug Discovery, 2012
Rithwik Ramachandran   +2 more
exaly  

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