Results 231 to 240 of about 234,943 (363)

Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis [PDF]

, 1997
Rosalía Diez‐Orejas, Gloria Molero, Federico Navarro, Jesús Plá, César Nombela, Miguel Sánchez‐Pérez   +5 more
openalex   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration. [PDF]

Mol Neurodegener
Kellett EA, Bademosi AT, Walker AK.
europepmc   +1 more source

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

, 1993
Ilja Vietor, Paul Schwenger, W Li, Joseph Schlessinger, J Vilček   +4 more
openalex   +1 more source

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

Research Progress on Anti-Inflammatory Mechanism of <i>Inula cappa</i>. [PDF]

Int J Mol Sci
Wu N, Wang S, Zhang Y, Wang S.
europepmc   +1 more source

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.

, 1993
Nidhi Gupta Williams, Hélène Paradis, Sadhana Agarwal, David L. Charest, Steven Pelech, Thomas M. Roberts   +5 more
openalex   +1 more source

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory [PDF]

, 1999
Sonja Blum, Amanda Moore, F. Adams, Pramod K. Dash   +3 more
openalex   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis. [PDF]

BMC Plant Biol
Huang X, Sun M, Du X, Quan L, Chao J, Deng X, Liao H.   +6 more
europepmc   +1 more source