Results 21 to 30 of about 1,463 (218)

Mitogen-activated protein kinase cascades in Vitis vinifera

Frontiers in Plant Science, 2015
Protein phosphorylation is one of the most important mechanisms to control cellular functions in response to external and endogenous signals. Mitogen-activated protein kinases (MAPK) are universal signaling molecules in eukaryotes that mediate the ...
Birsen eÇAKIR, Ozan eKılıçkaya
doaj   +1 more source

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [PDF]

Journal of Biological Chemistry, 2017
The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α.
Bassi, Rekha, Burgoyne, Joseph R, DeNicola, Gian F, Rudyk, Olena, DeSantis, Vittorio, Charles, Rebecca L, Eaton, Philip, Marber, Michael S   +7 more
openaire   +3 more sources

PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression

Molecular & Cellular Oncology, 2017
Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-
Leslie Ann Caromile, Linda H. Shapiro
doaj   +1 more source

Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage

Journal of Pharmacological Sciences, 2011
.: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao, Yoji Kyotani, Satoyasu Itoh, Hitoshi Nakayama, Minoru Isosaki, Masanori Yoshizumi   +5 more
doaj   +1 more source

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization. [PDF]

PLoS ONE, 2012
BACKGROUND: The response of the postnatal heart to growth and stress stimuli includes activation of a network of signal transduction cascades, including the stress activated protein kinases such as p38 mitogen-activated protein kinase (MAPK), c-Jun NH2 ...
Hamid el Azzouzi, Stefanos Leptidis, Meriem Bourajjaj, Marc van Bilsen, Paula A da Costa Martins, Leon J De Windt   +5 more
doaj   +1 more source

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj   +1 more source

Differential Induction of Tobacco MAP Kinases by the Defense Signals Nitric Oxide, Salicylic Acid, Ethylene, and Jasmonic Acid

Molecular Plant-Microbe Interactions, 2000
In tobacco, two mitogen-activated protein (MAP) kinases, designated salicylic acid (SA)-induced protein kinase (SIPK) and wounding-induced protein kinase (WIPK) are activated in a disease resistance-specific manner following pathogen infection or ...
Dhirendra Kumar, Daniel F. Klessig
doaj   +1 more source

Intraoperative electroacupuncture relieves remifentanil-induced postoperative hyperalgesia via inhibiting spinal glial activation in rats

Molecular Pain, 2017
Background Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance postoperative pain.
Changxi Shi, Yue Liu, Wei Zhang, Yishan Lei, Cui’e Lu, Rao Sun, Yu’e Sun, Ming Jiang, Xiaoping Gu, Zhengliang Ma   +9 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source