Results 51 to 60 of about 234,943 (363)

Thrombomodulin Regulation of Mitogen-Activated Protein Kinases [PDF]

International Journal of Molecular Sciences, 2019
The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. Recently, coagulation factors have also emerged as key players in regulating intracellular signaling pathways during inflammation. Among
Sumith R. Panicker, Hemant Giri, Alireza R. Rezaie, Alireza R. Rezaie, Xiaofeng Cai, Indranil Biswas   +5 more
openaire   +2 more sources

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations

Frontiers in Bioscience-Landmark, 2022
Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have ...
Khoa Nguyen, Hassan Yousefi, Thomas Cheng, Justin Magrath, Alifiani B. Hartono, Madlin Alzoubi, Katherine Hebert, Courtney K. Brock, Maryl K. Wright, Charles Ethan Byrne, Andrew Rivera, Sam C. Okpechi, Margarite Delores Matossian, Henri Wathieu, Steven Elliott, Mark J. Mondrinos, Sean B. Lee, Bridgette M. Collins-Burow, Suresh K. Alahari, David H. Drewry, Matthew E. Burow   +20 more
doaj   +1 more source

Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes [PDF]

, 2005
Background During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase.
Golden, E.B., Grasso-Knight, G., Leboy, P.S., Reilly, G.C.   +3 more
core   +3 more sources

MAP2K4 (mitogen-activated protein kinase kinase 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on MAP2K4 (mitogen-activated protein kinase kinase 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Nakayama, K, Nakayama, N, Miyazaki, K
openaire   +3 more sources

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]

, 2015
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine, Gray, Nathanael S, Hellman, Judith, Khakpour, Samira, Prakash, Arun, Sundar, Shirin, Tran, Alphonso, Wang, Jinhua, Wilhelmsen, Kevin, Xu, Fengyun   +9 more
core   +1 more source

Differential Induction of Tobacco MAP Kinases by the Defense Signals Nitric Oxide, Salicylic Acid, Ethylene, and Jasmonic Acid

Molecular Plant-Microbe Interactions, 2000
In tobacco, two mitogen-activated protein (MAP) kinases, designated salicylic acid (SA)-induced protein kinase (SIPK) and wounding-induced protein kinase (WIPK) are activated in a disease resistance-specific manner following pathogen infection or ...
Dhirendra Kumar, Daniel F. Klessig
doaj   +1 more source

Subfamily C7 Raf‐like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana [PDF]

Summary The calcium‐dependent protein kinase CPK28 regulates several stress pathways in multiple plant species. Here, we aimed to discover CPK28‐associated proteins in Arabidopsis thaliana.
Cameron, Emma, Derbyshire, Paul, Dharmasena, Thakshila, Doss, Bassem, Gonçalves Dias, Márcia, Mahathanthrige, Tharika, Menke, Frank L H, Monaghan, Jacqueline, Rawat, Anamika, Rodriguez Gallo, Maria Camila, Siegel, Kristen R, Sklenar, Jan, Uhrig, R Glen, Zipfel, Cyril   +13 more
core   +1 more source

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase [PDF]

Journal of Biological Chemistry, 1998
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements but did not affect genes lacking an AP-1 response element in their promoters.
Frank W. Hobbs, Elizabeth J. Manos, Richard A. Earl, James M. Trzaskos, Deborah A. Stradley, Robert A. Copeland, Kurumi Y. Horiuchi, Ronald L. Magolda, Pitts William J, Drew E. Van Dyk, Margaret F. Favata, Andrea J. Daulerio, Peggy Scherle, Wendi S. Feeser   +13 more
openaire   +2 more sources