Results 81 to 90 of about 218,105 (212)

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs

mBio, 2018
In all eukaryotic kingdoms, mitogen-activated protein kinases (MAPKs) play critical roles in cellular responses to environmental cues. These MAPKs are activated by phosphorylation at highly conserved threonine and tyrosine residues in response to ...
Carmen Herrero-de-Dios, Alison M. Day, Anna T. Tillmann, Stavroula L. Kastora, David Stead, Paula S. Salgado, Janet Quinn, Alistair J. P. Brown   +7 more
doaj   +1 more source

Farnesoid X Receptor (FXR) Agonists and Protein Kinase Regulation in NAFLD and NASH: Mechanisms and Therapeutic Potential

Kinases and Phosphatases
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic condition characterized by hepatic lipid deposits, insulin resistance, and inflammation which may progress to non-alcoholic steatohepatitis (NASH) and fibrosis.
Ayan Saha, Emily Wood, Luna Omeragic, Maya Minkara, Kethain Marma, Shipan Das Gupta, Jannatul Ferdoush   +6 more
doaj   +1 more source

The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

Journal of Ginseng Research, 2015
Background: Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are the major active ingredients
Bo Ra Jeon, Su Jung Kim, Seung Bok Hong, Hwa-Jin Park, Jae Youl Cho, Man Hee Rhee   +5 more
doaj   +1 more source

The Expression Profiles and Clinical Significance of Mixed Lineage Kinases in Glioma

Mediators of Inflammation
Mixed lineage kinases (MLKs), comprising seven members: MLK1-4, dual leucine zipper kinase (DLK), leucine zipper kinase (LZK), and sterile alpha motif and leucine zipper containing kinase (ZAK), belong to the mitogen-activated protein kinase kinase ...
Jin Huang, Yuankun Liu, Gaosong Wang, Yuning Chen, Yifan Shen, Jiahao Zhang, Wei Ji, Junfei Shao   +7 more
doaj   +1 more source

Editorial: Mitogen Activated Protein Kinases [PDF]

Frontiers in Cell and Developmental Biology, 2017
Cuenda, Ana, Lizcano, José M., Lozano, José   +2 more
openaire   +3 more sources

PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs), which are known to regulate lipid homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling.
Maria Moreno, Assunta Lombardi, Elena Silvestri, Rosalba Senese, Federica Cioffi, Fernando Goglia, Antonia Lanni, Pieter de Lange   +7 more
doaj   +1 more source

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S., Edwards, J., Krishnan, S., Witton, C.J.   +3 more
core  

Identification of mitogen-activated protein kinases substrates in Arabidopsis using kinase client assay

Plant Signaling & Behavior
Mitogen-activated protein kinase (MPK) cascades are essential signal transduction components that control a variety of cellular responses in all eukaryotes.
Sunghwa Bahk, Nagib Ahsan, Jonguk An, Sun Ho Kim, Zakiyah Ramadany, Jong Chan Hong, Jay J. Thelen, Woo Sik Chung   +7 more
doaj   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Overcoming reduced glucocorticoid sensitivity in airway disease:molecular mechanisms and therapeutic approaches [PDF]

, 2010
Abraham, Adcock, Ali, Allfrey, Auphan, Barnes, Barnes, Barnes, Barnes, Bartholome, Bartling, Bartling, Bateman, Beesley, Bergeron, Bhavsar, Bhavsar, Bourbeau, Cai, Calverley, Carmichael, Carrabino, Charmandari, Chen, Cho, Chung, Chung, Chung, Ciencewicki, Condliffe, Cosio, Cosio, Culpitt, Culpitt, Denslow, Duma, Evans, Ferreira, Fitzpatrick, Freedman, Gagliardo, Galasinski, Galliher-Beckley, Galliher-Beckley, Goleva, Gross, Gross, Hakonarson, Haller, Hew, Hogg, Hwang, Ian M. Adcock, Irusen, Ito, Ito, Ito, Ito, Ito, Ito, Jatakanon, John, John A. Marwick, Karp, Keatings, Kian Fan Chung, King, Kino, Kitagawa, Kleiman, Knoepfler, Konstan, Korn, Kovacs, Krstic, Kumar, Kumar, Kurashima, Laffargue, Langhoff, Lee, Lee, Lewis-Tuffin, Li, Li, Liu, Lu, Macedo, Mak, Mannino, Marone, Marwick, Marwick, Marwick, Marwick, Marwick, Matysiak, Meagher, Medicherla, Meja, Miller, Molnarfi, Moore, Murphy, Muselet-Charlier, Onda, Osoata, OʼSullivan, Pace, Patel, Pratt, Pujols, Pujols, Rahman, Rahman, Raia, Reichardt, Renda, Rennard, Rhen, Rogatsky, Rommel, Rottner, Rumora, Saccani, Sadhu, Sasaki, Schacke, Scheinman, Schermer, Sethi, Silverstein, Smith, Smolonska, Stav, Strickland, Suissa, Szatmuíry, Thomson, Tomlinson, Tuckermann, Tudhope, Ukena, Usmani, van Rensen, Verhaeghe, Ward, Ward, Wood, Wright, Young   +150 more
core   +1 more source