Results 281 to 290 of about 40,054 (307)
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Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer
Cancer and Metastasis Reviews, 2007The mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are a family of dual-specificity protein phosphatases that dephosphorylate both phospho-threonine and phospho-tyrosine residues in MAP kinases, including the c-Jun N-terminal protein kinase (JNK)/stress-activated protein kinase (SAPK), the p38 MAPK, and the extracellular signal-related ...
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Microtubule Disruption and Tumor Suppression by Mitogen-Activated Protein Kinase Phosphatase 4
Cancer Research, 2007Abstract The extracellular signal-regulated kinase (Erk) is one of the downstream effectors of the Ras pathway whose activation is essential for the proliferation and survival of cancer cells. Erk activation is negatively regulated by mitogen-activated protein kinase (MAPK) phosphatases (MKP), which are generally up-regulated by Erk ...
Yuangang, Liu +4 more
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Structural organization of the rat mitogen-activated protein kinase phosphatase 2 gene
Gene, 2001Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are dual specificity protein phosphatases that specifically inactivate MAPKs. Regulated expression of MKPs plays a key role in determining their physiological function. However, little is known about the molecular mechanism of the activation of MKP genes. In this study, we cloned the rat MKP-2
T, Zhang, M, Choy, M, Jo, M S, Roberson
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The mitogen-activated protein kinase phosphatase PHS1 regulates flowering in Arabidopsis thaliana
Planta, 2015Arabidopsis PHS1, initially known as an actor of cytoskeleton organization, is a positive regulator of flowering in the photoperiodic and autonomous pathways by modulating both CO and FLC mRNA levels. Protein phosphorylation and dephosphorylation is a major type of post-translational modification, controlling many biological processes.
Tang, Qian +6 more
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Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone
Molecular and Cellular Endocrinology, 2001The aim of these studies was to identify the signaling mechanism(s) that contribute to GnRH-induced expression of MAPK phosphatase (MKP)-2, a dual specificity phosphatase that selectively inactivates MAPKs. GnRH receptor activation induced MKP-2 expression in both clonal (alphaT3-1) and primary gonadotropes.
T, Zhang, J M, Mulvaney, M S, Roberson
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Biochemical Society Transactions, 2006
ERK (extracellular-signal-regulated kinase) is a MAPK (mitogen-activated protein kinase), which regulates diverse physiological functions including cell proliferation, differentiation, transformation and survival. It is now clear that in addition to the duration and magnitude of signalling through this MAPK pathway, the spatial restriction of MAPK ...
Karlsson, M., Mandl, M., Keyse, S M
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ERK (extracellular-signal-regulated kinase) is a MAPK (mitogen-activated protein kinase), which regulates diverse physiological functions including cell proliferation, differentiation, transformation and survival. It is now clear that in addition to the duration and magnitude of signalling through this MAPK pathway, the spatial restriction of MAPK ...
Karlsson, M., Mandl, M., Keyse, S M
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Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.
Molecular cancer research : MCR, 2004Mitogen-activated protein kinases (MAPKs) mediate signaling from the cell membrane to the nucleus following their phosphorylation at conserved threonine and tyrosine residues within their activation loops. We show that protein tyrosine phosphatase epsilon (PTP epsilon) inhibits ERK1 and ERK2 kinase activity and reduces their phosphorylation; in ...
Hila, Toledano-Katchalski +7 more
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Crystal structure of a novel mitogen‐activated protein kinase phosphatase, SKRP1
Proteins: Structure, Function, and Bioinformatics, 2011Chun Hua, Wei +6 more
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Mitogen‐activated protein kinase cascades in plant signaling
Journal of Integrative Plant Biology, 2022Mengmeng Zhang, Shuqun Zhang
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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Nature Reviews Drug Discovery, 2007Kate L Jeffrey, Montserrat Camps
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