Results 271 to 280 of about 40,054 (307)

Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade

European Journal of Pharmacology, 1999
Mitogen-activated protein kinases (MAPKs) are activated by various stimuli, such as growth factors, cytokines, or stress, and are considered to be important mediators in intracellular signal transduction networks. The dual-specificity kinases, MAPK kinases (MKKs), which phosphorylate the TXY motif in the catalytic domain of MAPKs, can cause the ...
M, Haneda, T, Sugimoto, R, Kikkawa
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MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus

Lupus, 2012
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles. The production of these cytokines is responsible for the mitogen-activated protein kinases (MAPKs), which can ...
J, Yang, Y-W, Lu, M-M, Lu, R-X, Leng, H-F, Pan, D-Q, Ye   +5 more
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Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation

Neuroscience, 2022
Morphine is an opioid drug often used in treating moderate to severe pain. However, morphine tolerance in patients limits its used in clinical settings. Our previous study showed that a cannabinoid type 2 (CB2) receptor agonist attenuated morphine tolerance.
Qingling, Kong, Songyu, Tian, Chao, Ma, Guonian, Wang, Mingyue, Zhang   +4 more
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Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kenji, Ashida, Kiminobu, Goto, Yue, Zhao, Taijiro, Okabe, Toshihiko, Yanase, Ryoichi, Takayanagi, Masatoshi, Nomura, Hajime, Nawata   +7 more
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Mitogen-activated protein kinase phosphatase-1 in olfactory neural regeneration

NeuroReport, 2000
Uniquely, olfactory neurons continuously replace themselves. Olfactory bulb ablation induces coordinated degeneration and regeneration in olfactory neuroepithelium; up-regulated growth factors bind to their receptors, initiating a phosphorylation cascade activating mitogen-activated protein kinases (MAPK).
M, Shinogami, T, Ishibashi
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Regulation of tristetraprolin expression by mitogen‐activated protein kinase phosphatase‐1

APMIS, 2012
Tristetraprolin (TTP) is an acute phase protein, and its expression is rapidly up‐regulated by inflammatory signals, such as lipopolysaccharide (LPS) and cytokines. TTP regulates gene expression by governing the mRNA stability of its target genes, which include cytokines and growth factors. MAP kinase phosphatase‐1 (MKP‐1) is a nuclear phosphatase that
Noora, Huotari, Tuija, Hömmö, Ville, Taimi, Riina, Nieminen, Eeva, Moilanen, Riku, Korhonen   +5 more
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Mitogen-Activated Protein Kinase Phosphatases in Metabolism

2013
Although we continue to learn much about how the mitogen-activated protein kinases (MAPKs) are involved in physiological and pathophysiological signaling in metabolism, a comparable level of understanding about the mechanisms of MAPK inactivation in the control of metabolic homeostasis is lacking.
Ahmed Lawan, Anton M. Bennett
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Induction of Mitogen-Activated Protein Kinase Phosphatase-1 During Acute Hypertension

Hypertension, 1997
Abstract Recently, we demonstrated that elevated blood pressure activates mitogen-activated protein (MAP) kinases in rat aorta. Here we provide evidence that the vascular response to acute hypertension also includes induction of MAP kinase phosphatase-1 (MKP-1), which has been shown to function in the dephosphorylation and ...
Q, Xu, T W, Fawcett, M, Gorospe, K Z, Guyton, Y, Liu, N J, Holbrook   +5 more
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Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1

Bioorganic & Medicinal Chemistry, 2006
Protein tyrosine phosphatases have a central role in the maintenance of normal cellular functionality. For example, PTP1B has been implicated in insulin-resistance, obesity, and neoplasia. Mitogen-activated protein kinase phosphatase-1 (MKP-1 or DUSP1) dephosphorylates and inactivates mitogen-activated protein kinase (MAPK) substrates, such as p38, JNK,
John S, Lazo, Ruth, Nunes, John J, Skoko, Pierre E, Queiroz de Oliveira, Andreas, Vogt, Peter, Wipf   +5 more
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Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium

Journal of Cardiac Failure, 2002
Mitogen-activated protein kinases (MAPKs), consisting of the ERK1/2, JNKs, and p38-kinase families, play a key role in the regulation of myocyte growth and apoptosis in vitro. The activity of MAPKs is regulated by dual-specificity MAPK phosphatases (MKPs). Because myocardial failure is associated with myocyte hypertrophy and apoptosis, MAPKs may play a
Catherine, Communal, Wilson S, Colucci, Andrea, Remondino, Douglas B, Sawyer, J David, Port, Scott E, Wichman, Michael R, Bristow, Krishna, Singh   +7 more
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