Results 161 to 170 of about 142,015 (255)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Unraveling the cryptic functions of mitogen-activated protein kinases Cpk2 and Mpk2 in <i>Cryptococcus neoformans</i>. [PDF]

mBio
Jang Y-B, Kim J-Y, Bahn Y-S.
europepmc   +1 more source

Mechanisms of Dendrobium officinale polysaccharides in repairing gastric mucosal injuries based on mitogen-activated protein kinases (MAPK) signaling pathway. [PDF]

Bioengineered, 2022
Ma S, Wu Q, Zhao Z, Xiong J, Niu J, Liu C, Liu T, Chai Y, Qu X, Ma Z, Zhang L, Pu X.   +11 more
europepmc   +1 more source

Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold. [PDF]

Nat Commun
Póti ÁL, Bálint D, Alexa A, Sok P, Ozsváth K, Albert K, Turczel G, Magyari S, Ember O, Papp K, Király SB, Imre T, Németh K, Kurtán T, Gógl G, Varga S, Soós T, Reményi A.   +17 more
europepmc   +1 more source

Physical Exercise-Induced Astrocytic Neuroprotection and Cognitive Improvement Through Primary Cilia and Mitogen-Activated Protein Kinases Pathway in Rats With Chronic Cerebral Hypoperfusion. [PDF]

Front Aging Neurosci, 2022
Cao W, Lin J, Xiang W, Liu J, Wang B, Liao W, Jiang T.   +6 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Hypoxia Regulates the Extracellular Matrix via Mitogen-Activated Protein Kinases Pathway in Cells Retrieved from the Human Intervertebral Disc. [PDF]

Yonsei Med J, 2021
Kang YM, Shin EJ, Lee BH, Yang JH, Lee HM, Moon SH.   +5 more
europepmc   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

Mitogen-Activated Protein Kinases 3/6 Reduce Auxin Signaling via Stabilizing Indoleacetic Acid-Induced Proteins 8/9 in Plant Abiotic Stress Adaptation. [PDF]

Int J Mol Sci
Wang C, Li X, Zhao H, Cui X, Xu W, Li K, Xu Y, Yu Z, Yu L, Guo R.   +9 more
europepmc   +1 more source

Arctigenin attenuates paraquat-induced human lung epithelial A549 cell injury by suppressing ROS/p38 mitogen-activated protein kinases-mediated apoptosis. [PDF]

World J Emerg Med, 2022
Liu C, Sun ZR, Wang MM, Yang ZZ, Zhang W, Ren Y, Han XQ, Liu R, Li Q, Nie SN.   +9 more
europepmc   +1 more source