Results 91 to 100 of about 90,988 (285)

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study

BMC Cancer, 2010
Background Mitomycin C is a chemotherapeutic agent used in the treatment of peritoneal surface malignancies, administered as hyperthermic intraperitoneal chemotherapy after cytoreductive surgery.
Sørensen Olaf, Andersen Anders, Olsen Harald, Alexandr Kristian, Ekstrøm Per Olaf, Giercksky Karl-Erik, Flatmark Kjersti   +6 more
doaj   +1 more source

Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation

International Journal of Oncology, 2016
Mitomycin C (MC), a commonly used anticancer drug, induces DNA damage via DNA alkylation. Decarbamoyl mitomycin C (DMC), another mitomycin lacking the carbamate at C10, generates similar lesions as MC. Interstrand cross-links (ICLs) are believed to be the lesions primarily responsible for the cytotoxicity of MC and DMC. The major ICL generated by MC (α-
Cheng, Shu-Yuan, Seo, Jiwon, Huang, Bik Tzu, Napolitano, Tanya, Champeil, Elise   +4 more
openaire   +3 more sources

A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck [PDF]

, 2005
Objective: The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and
Bernier J, Budach W, Colevas AD, Colleoni M, Conti F, De Placido S, Degardin M, Dische S, Dobrowsky W, Gasparini G, Gralla R, Grau C, Haffty BG, Harrison LB, Hehr T, Kies MS, Koch WM, Munker R, Pouillart P, Poulsen MG, Regine WF, Shin DM, Siu LL, Vici P, Vokes EE, Wendt TG   +25 more
core   +1 more source

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, EarlyView.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Transconjunctival penetration of mitomycin C

Indian Journal of Ophthalmology, 2008
Aims: The study was performed to estimate transconjunctival penetration of mitomycin C (MMC) to Tenon′s tissue following application over the intact conjunctiva before routine trabeculectomy. Settings and Design: Institution-based case series.
Velpandian T, Sihota Ramanjit, Sinha Ankur, Gupta Viney   +3 more
doaj  

Determination of mitomycin C in rat plasma by liquid chromatography-tandem mass spectrometry and its application for determining pharmacokinetics in rat

Heliyon
To develop the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring mitomycin C in rat plasma, samples were processed using solid-phase extraction, with the internal standard being carbamazepine. A reversed phased C18 column was
Kyung-Sun Moon, Jong-Min Song, JiMin Yi, Quynh Khoa Pham, Sung-Hoon Ahn   +4 more
doaj   +1 more source

Comparison of triamcinolone and mitomycin C nasal pack in functional endoscopic sinus surgery: a randomized, clinical trial

The Egyptian Journal of Otolaryngology, 2018
Aims and Objectives Synechia formation in a postoperative nasal cavity is a major factor for suboptimal clinical outcome in functional endoscopic sinus surgery (FESS).
Natarajan Ramalingam, Pradipta K. Parida, Sunil K. Saxena, Gopalakrishnan Surianarayanan   +3 more
doaj   +1 more source

Bacteriocins contributing in Rhizospheric competition among Fluorescent Pseudomonads [PDF]

, 2016
Aims: To examine the production of bacteriocins through the study of a group of rhizospheric Pseudomonas isolates already known to produce metabolites that are antagonistic to fungi. Methodology: Fourteen rhizospheric strains of fluorescent Pseudomonads
Guechi, A., Haichour, N., Mezaache-Aichour, S., Nicklin, Jane, Zerroug, M.   +4 more
core   +1 more source