Results 71 to 80 of about 85,416 (247)

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages [PDF]

, 2019
open access articlePurpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon.
Capparelli, Rosanna, Capuano, Federico, Contaldi, Felice, Della Ventura, Bartolomeo, Fulgione, Andrea, Giannini, Cinzia, Ianniello, Flora, Lelli, Marco, Papaianni, Marina, Pastore, Stella, Roveri, Norberto, Sgamma, Tiziana, Velotta, Raffaele   +12 more
core   +2 more sources

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Heat-activated intravenous liposomal doxorubicin combined with mitomycin C hyperthermic intravesical chemotherapy (HIVEC) for treatment of bladder cancer

International Journal of Hyperthermia
Purpose To evaluate the safety and pharmacokinetics of lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox®) combined with mitomycin C (MMC) hyperthermic intravesical chemotherapy (HIVEC) as a potential treatment for non-muscle invasive bladder ...
Andrew S. Mikhail, Sandeep Gurram, Vladimir A. Valera, Dieter Haemmerich, Nikhil Gopal, Ivane Bakhutashvili, William Richardson, Cody J. Peer, Matthew F. Starost, Charles Hesswani, Keith T. Schmidt, William D. Figg, John W. Karanian, William F. Pritchard, Bradford J. Wood   +14 more
doaj   +1 more source

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review [PDF]

Cancer Med
Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Kotian N, Reddy Y, Pai P, Sundara B.
europepmc   +2 more sources

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Continuous saline bladder irrigation for two hours following transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer does not prevent recurrence or progression compared with intravesical Mitomycin-C. [PDF]

, 2018
BackgroundIntravesical Mitomycin-C (MMC) following transurethral resection of bladder tumor (TURBT), while efficacious, is associated with side effects and poor utilization. Continuous saline bladder irrigation (CSBI) has been examined as an alternative.
Asanad, Kian, Blaibel, Maher, Chamie, Karim, Donin, Nicholas M, Lenis, Andrew T   +4 more
core   +2 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Mitomycin extravasation injury: A case series

JAAD Case Reports, 2021
Karolina Mieczkowska, BS, Alana Deutsch, BA, Bijal Amin, MD, Adnan Mir, MD, PhD, Renu Abraham, PharmD, Yevgeniy Balagula, MD, Rachel Blasiak, MD, MPH, Ranon E. Mann, MD, Parth Patel, MD, Tagai Musaev, MD, Tian Hao Zhu, MD, Shalom Kalnicki, MD, Stuart H. Packer, MD, Beth N. McLellan, MD   +13 more
doaj   +1 more source

Efficacy of mitomycin-C on anterior urethral stricture after internal urethrotomy: A systematic review and meta-analysis [version 3; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2020
Background and Aim Mitomycin-C is a potent agent that plays an important role in tissue healing and scar formation. This study aims to investigate the efficacy of Mitomycin-C in treating anterior urethral stricture after internal urethrotomy.
Irfan Wahyudi, Gampo Alam Irdam, Andy Andy   +2 more
doaj   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan, Evans, Christopher P   +1 more
core   +2 more sources