Results 101 to 110 of about 94,931 (305)

Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation

International Journal of Oncology, 2016
Mitomycin C (MC), a commonly used anticancer drug, induces DNA damage via DNA alkylation. Decarbamoyl mitomycin C (DMC), another mitomycin lacking the carbamate at C10, generates similar lesions as MC. Interstrand cross-links (ICLs) are believed to be the lesions primarily responsible for the cytotoxicity of MC and DMC. The major ICL generated by MC (α-
Cheng, Shu-Yuan, Seo, Jiwon, Huang, Bik Tzu, Napolitano, Tanya, Champeil, Elise   +4 more
openaire   +3 more sources

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, EarlyView.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: a prospective randomized study. [PDF]

, 2003
PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly increased transport rates compared with passive transport. We performed a prospective study in patients with high risk superficial bladder cancer to assess the efficacy ...
Capelli, G, Di Stasi, SM, Giannantoni, A, Massoud, R, Navarra, P, Stephen, RL, Vespasiani, G   +6 more
core   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Transconjunctival penetration of mitomycin C

Indian Journal of Ophthalmology, 2008
Aims: The study was performed to estimate transconjunctival penetration of mitomycin C (MMC) to Tenon′s tissue following application over the intact conjunctiva before routine trabeculectomy. Settings and Design: Institution-based case series.
Velpandian T, Sihota Ramanjit, Sinha Ankur, Gupta Viney   +3 more
doaj  

Determination of mitomycin C in rat plasma by liquid chromatography-tandem mass spectrometry and its application for determining pharmacokinetics in rat

Heliyon
To develop the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring mitomycin C in rat plasma, samples were processed using solid-phase extraction, with the internal standard being carbamazepine. A reversed phased C18 column was
Kyung-Sun Moon, Jong-Min Song, JiMin Yi, Quynh Khoa Pham, Sung-Hoon Ahn   +4 more
doaj   +1 more source

Comparison of triamcinolone and mitomycin C nasal pack in functional endoscopic sinus surgery: a randomized, clinical trial

The Egyptian Journal of Otolaryngology, 2018
Aims and Objectives Synechia formation in a postoperative nasal cavity is a major factor for suboptimal clinical outcome in functional endoscopic sinus surgery (FESS).
Natarajan Ramalingam, Pradipta K. Parida, Sunil K. Saxena, Gopalakrishnan Surianarayanan   +3 more
doaj   +1 more source

Hyperthermia combined with chemotherapy - Biological rationale, clinical application, and treatment results [PDF]

, 1999
There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40-44 degrees C) of cells or tumor tissues ...
Issels, Rolf-Dieter
core   +1 more source

Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) [PDF]

, 2023
Jannik Almasi, Frank Erdnüß, Judith Thiesen, Irene Krämer   +3 more
openalex   +1 more source

Clinical outcomes of the PAUL glaucoma implant in primary open‐angle and pseudoexfoliative glaucoma eyes after failed glaucoma surgeries

Acta Ophthalmologica, EarlyView.
Abstract Purpose This study assesses the PAUL® glaucoma implant (PGI) in primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) after failed glaucoma surgery. Given PEXG's more aggressive nature, limited research exists on PGI outcomes in this subgroup. This study aims to compare PGI's efficacy and safety in both conditions. Methods A
Constance Liegl, Leonie Bourauel, Benjamin Aretz, Diana Samarghitan, Wolfgang Walz, Michael Petrak, Frank G. Holz, Raffael Liegl, Karl Mercieca   +8 more
wiley   +1 more source