Results 121 to 130 of about 93,319 (307)
Validation of an HPLC-MS/MS and Wipe Procedure for Mitomycin C Contamination [PDF]
, 2014 Clayton B’Hymer +3 more
openalex +1 more source
Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis
The FEBS Journal, EarlyView.The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe +7 more
wiley +1 more source
International Medical Case Reports Journal, 2021 Majid Moshirfar,1– 3 William B West Jr,4 Dallin C Milner,5 Shannon E McCabe,1 Yasmyne C Ronquillo,1 Phillip C Hoopes1 1Hoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA; 2John A. Moran Eye Center, Department of Ophthalmology and Visual
Moshirfar M +5 more
doaj
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Southwest Respiratory and Critical Care Chronicles, 2015 Tracheal stenosis is an uncommon but known complication of endotracheal intubation and tracheostomy. Surgery is currently the definitive treatment for tracheal stenosis but carries a significantly higher risk for adverse events as it often involves ...
Audra Fuller +3 more
doaj
Internal Medicine Journal, EarlyView.Abstract Background Upper tracheal stenosis (UTS) is a rare process with multiple causes and variable approaches to treatment. Australian data on management patterns are lacking and patient resources reflecting local practices are scarce. Aims To describe the management strategies of UTS over 12 years among three teaching hospitals in New South Wales ...
Nathan Harb +6 more
wiley +1 more source
Antifibrotic effects of tocotrienols on human Tenon's fibroblasts [PDF]
, 2018 Purpose: To compare the antifibrotic effect of vitamin E isoforms α-, γ-, and δ-tocotrienol on human Tenon's fibroblasts (hTf) to the antimetabolite mitomycin C.
Frueh, Beatrice +7 more
core
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad +10 more
wiley +1 more source
Photochemistry and Photobiology, EarlyView.FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee +5 more
wiley +1 more source
Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model
Photochemistry and Photobiology, EarlyView.Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore +6 more
wiley +1 more source