Results 161 to 170 of about 361,857 (303)

Sex‐related changes in lactate dehydrogenase A expression differently impact the immune response in melanoma

open access: yesThe FEBS Journal, EarlyView.
Here, we explore a differential sex‐related metabolic‐immune relationship in melanoma. Melanoma tumours in male patients exhibit a higher LDH‐A‐driven production of lactate compared to their female counterparts. In turn, lactate acts as an immunosuppressive molecule, promoting pro‐tumoural Treg cells and suppressing anti‐tumoural CD8+ T‐cell activity ...
Marta Iozzo   +10 more
wiley   +1 more source

Methods for direct determination of mitomycin C in aqueous solutions and in urine

open access: yesBiological Procedures Online, 1998
Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC) alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy with MMC.
Palecek Emil   +3 more
doaj  

Selectivity and anti‐tumor immune elevation by vascular‐targeted photodynamic therapy of mouse orthotopic bladder cancer model

open access: yesPhotochemistry and Photobiology, EarlyView.
Vascular‐targeted photodynamic therapy (VTP) using the photosensitizer WST11 is a non‐surgical tumor ablation approach. Light activation of WST11 leads to excessive generation of reactive oxygen species, which causes tumor vascular arrest, followed by destruction of tumor blood vessels and tumor necrosis.
Jie Chen   +8 more
wiley   +1 more source

Cytomorphological Effects of Mitomycin C on Urothelial Cells: Eosinophils May Be Clue to The Drug-Induced Changes [PDF]

open access: yesCell Journal, 2014
Cytomorphological changes of mitomycin C on urothelial cells may be misinterpreted as a neoplastic process. A 60-year old male patient who was given an eight-week course of intravesical mitomycin C due to non-invasive low grade transitional cell ...
Gulcin Guler Simsek   +2 more
doaj  

Breaking the Complexity of Cancer Using Computational Transcriptomic Network Biology

open access: yesWIREs Computational Statistics, Volume 17, Issue 2, June 2025.
ABSTRACT While the landscapes of cancer mutations have been mostly clarified, in this study, we focused on the connective aggregates between mutations and phenotypes, named here as “gene transcriptomic networks,” aiming to survey computational network biology processes that have achieved significant results in cancer biology.
Heewon Park, Satoru Miyano
wiley   +1 more source

The Riboflavin-sensitized Photooxidation of Mitomycin C by Near Ultraviolet Light Irradiation [PDF]

open access: yes, 1981
The riboflavin-sensitized photodestruction of mitomycin C by the irradiation with near ultraviolet light was investigated. The irradiation with near ultraviolet light abruptly decomposed mitomycin C in the presence of riboflavin, but mitomycin C slowly ...
Ueda Kazuo
core   +1 more source

Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
The study reports that Wnt inhibitors safeguard porcine embryonic stem cells (ESCs) from acquiring the extraembryonic endoderm (XEN) lineage, and further develop an efficient strategy to derive XEN cells from ESCs. The XEN cells from ESCs exhibit similar transcriptome and chromatin accessibility features to XEN cells from embryos and contribute to ...
Hanning Wang   +4 more
wiley   +1 more source

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