Results 171 to 180 of about 361,857 (303)

Outcomes in BCG failure: Outcome from a single centre UK experience

open access: yesBJUI Compass, Volume 6, Issue 5, May 2025.
Abstract Objective To describe real‐world outcomes of patients with BCG failure undergoing bladder‐sparing treatments (BSTs) vs radical cystectomy in the UK. Patients and Methods A single institution audit was conducted at a tertiary bladder cancer referral service (UCLH, London, UK). Patients with BCG failure treated between January 2017 and September
Elizabeth Day   +6 more
wiley   +1 more source

Advancements in Diagnostics and Therapeutics for Cancer of Unknown Primary in the Era of Precision Medicine

open access: yesMedComm, Volume 6, Issue 5, May 2025.
In clinical practice, routine examinations for patients with CUP include taking a medical history, conducting a physical examination, and detecting serum tumor markers. In addition, IHC or MTP‐based methodologies were suggested to assist in identifying the tissue origin of CUP and guiding site‐specific therapy for CUP.
Ting Zhao   +5 more
wiley   +1 more source

Assessing the efficacy and safety of sequential intravesical gemcitabine and docetaxel – does time from transurethral resection of bladder tumour to induction matter?

open access: yes
BJU International, EarlyView.
Ian M. McElree   +6 more
wiley   +1 more source

Sotorasib Is Not Effective in a KRAS‐Mutated Patient With Brain Metastases From Lung Adenocarcinoma due to Multiple Gene Co‐Mutations

open access: yesRespirology Case Reports, Volume 13, Issue 5, May 2025.
We report a case of brain metastasis that occurred during the standard post‐operative treatment for early‐stage NSCLC. Initial multiplex test was performed using the brain metastatic tissue, and the KRAS G12C mutation was detected. However, the response to Sotorasib treatment was not observed.
Takayuki Suetsugu   +9 more
wiley   +1 more source

Interleukin‐24: A Multidimensional Therapeutic for Treatment of Human Diseases

open access: yesWIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 3, May/June 2025.
The discovery of interleukin (IL)‐24 and studying its biological activity demonstrate its potential to serve as a therapeutic for human diseases, especially for cancer treatment. Image created with BioRender.com. ABSTRACT The field of targeted therapy exploits the selective expression of therapeutic genes or proteins in diseased cells.
Rajeswari Raguraman   +2 more
wiley   +1 more source

Tumor innervation in cervical cancer: Prognostic insights from myelin‐associated risk signatures

open access: yesFASEB BioAdvances, Volume 7, Issue 5, May 2025.
Analyses of publicly available cancer genomics data with respect to Schwann cells relevant signatures can provide important insights. Chen et al. show that intratumoral innervation promotes cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) metastasis. Higher nerve density impairs immune cell infiltration, reduces the expression of
Guoqiang Chen   +9 more
wiley   +1 more source

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